Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers

被引：8

作者：

Azzolina, Danila ^{[1
,2
]}

Consonni, Dario ^{[3
]}

Ferrante, Daniela ^{[4
]}

Mirabelli, Dario ^{[5
,6
]}

Silvestri, Stefano ^{[4
]}

Luberto, Ferdinando ^{[7
]}

Angelini, Alessia ^{[4
]}

Cuccaro, Francesco ^{[8
]}

Nannavecchia, Anna Maria ^{[8
]}

Oddone, Enrico ^{[9
,10
]}

Vicentini, Massimo ^{[7
]}

Barone-Adesi, Francesco ^{[11
]}

Cena, Tiziana ^{[4
]}

Mangone, Lucia ^{[7
]}

Roncaglia, Francesca ^{[7
]}

Sala, Orietta ^{[12
]}

Menegozzo, Simona ^{[13
]}

Pirastu, Roberta ^{[14
]}

Tunesi, Sara ^{[4
]}

Chellini, Elisabetta ^{[15
]}

Miligi, Lucia ^{[15
]}

Perticaroli, Patrizia ^{[16
]}

Pettinari, Aldo ^{[16
]}

Bressan, Vittoria ^{[17
]}

Merler, Enzo ^{[18
]}

Girardi, Paolo ^{[18
,19
]}

Bisceglia, Lucia ^{[20
]}

Marinaccio, Alessandro ^{[21
]}

Massari, Stefania ^{[21
]}

Magnani, Corrado ^{[4
]}

机构：

[1] Univ Ferrara, Environm & Prevent Sci, I-44121 Ferrara, Italy

[2] Univ Ferrara, Ferrara, Italy

[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Unit Epidemiol, Milan, Italy

[4] Univ Piemonte Orientale Amedeo Avogadro, Dept Translat Med, Unit Med Stat & Canc Epidemiol, Novara, Italy

[5] CPO Piedmont, Unit Canc Epidemiol, Turin, Italy

[6] Univ Turin, Turin, Italy

[7] Azienda Unita Sanit Locale IRCCS Reggio Emilia, Epidemiol Unit, Reggio Emilia, Italy

[8] Local Hlth Unit Barletta Andria Trani, Unit Epidemiol & Stat, Barletta, Italy

[9] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Pavia, Italy

[10] ICS Maugeri IRCCS, Pavia, Italy

[11] Univ Piemonte Orientale, Dept Translat Med, Unit Publ Hlth, Novara, Italy

[12] Reg Agcy Protect Environm & Energy Emilia Romagna, Reggio Emilia, Italy

[13] Natl Canc Inst IRCCS Fdn Pascale, Naples, Italy

[14] Sapienza Univ, Dept Biol & Biotechnol Charles Darwin, Rome, Italy

[15] Inst Canc Res, Occupat & Environm Epidemiol Unit, Prevent & Clin Network ISPRO, Florence, Italy

[16] ASUR Marche, Prevent Dept, Senigallia, Italy

[17] UOSD Serv Epidemiol AULSS6 EUGANEA, Padua, Italy

[18] Local Hlth Unit 6, Reg Epidemiol Syst, Padua, Italy

[19] Univ Padua, Dept Dev & Social Psychol, Dept Stat Sci, Padua, Italy

[20] Apulia Reg Agcy Hlth & Social Pol ARESS Puglia, Bari, Italy

[21] Italian Workers Compensat Author INAIL, Dept Occupat & Environm Med, Unit Occupat & Environm Epidemiol, Epidemiol & Hyg, Rome, Italy

来源：

THORAX | 2023年 / 78卷 / 08期

关键词：

lung cancer; mesothelioma; asbestos induced lung disease; POOLED ANALYSIS; LATENCY PERIOD; RELATIVE RISK; ITALIAN POOL; MORTALITY; COHORT; SMOKING; BURDEN; TRENDS; IMPACT;

D O I：

10.1136/thorax-2021-217862

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

IntroductionExposure to asbestos increases the risk of lung cancer and mesothelioma. Few studies quantified the premature occurrence of these diseases in asbestos-exposed workers. Focus on premature disease onset (rate advancement or acceleration) can be useful in risk communication and for the evaluation of exposure impact. We estimated rate advancement for total mortality, lung cancer and pleural mesothelioma deaths, by classes of cumulative asbestos exposure in a pooled cohort of asbestos cement (AC) workers in Italy. MethodThe cohort study included 12 578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE). ResultAcceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE. ConclusionThe current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality.

引用

页码：808 / 815

页数：8

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