A novel whole-head RF coil design tailored for concurrent multichannel brain stimulation and imaging at 3T

被引:6
作者
Lara, Lucia I. Navarro de [1 ,2 ,6 ]
Stockmann, Jason P. [1 ,2 ]
Meng, Qinglei [1 ,2 ]
Keil, Boris [1 ,3 ,4 ]
Mareyam, Azma [1 ]
Uluc, Isil [2 ]
Daneshzand, Mohammad [1 ,2 ]
Makarov, Sergey [1 ,2 ,5 ]
Wald, Lawrence L. [1 ,2 ]
Nummenmaa, Aapo [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA 02129 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
[3] TH Mittelhessen Univ Appl Sci, Inst Med Phys & Radiat Protect, Dept Life Sci Engn, Giessen, Germany
[4] Phillipps Univ Marburg, Univ Hosp Marburg, Dept Diagnost & Intervent Radiol, Marburg, Germany
[5] Comp Engn Worcester Polytech Inst, Dept Elect, Worcester, MA 01609 USA
[6] Massachusetts Gen Hosp, Harvard Med Sch, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, 149 13th St, Charlestown, MA 02129 USA
关键词
MTMS; Simultaneous TMS; fMRI; Non-invasive brain stimulation; Whole-head RF coil; COMBINED TMS/FMRI; ARRAY; TMS; FMRI;
D O I
10.1016/j.brs.2023.05.025
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: Multichannel Transcranial Magnetic Stimulation (mTMS) [1] is a novel non-invasive brain stimulation technique allowing multiple sites to be stimulated simultaneously or sequentially under electronic control without movement of the coils. To enable simultaneous mTMS and MR imaging, we have designed and constructed a whole-head 28-channel receive-only RF coil at 3T. Methods: A helmet-shaped structure was designed considering a specific layout for a mTMS system with holes for positioning the TMS units next to the scalp. Diameter of the TMS units defined the diameter of RF loops. The placement of the preamplifiers was designed to minimize possible interactions and to allow straightforward positioning of the mTMS units around the RF coil. Interactions between TMS-MRI were analyzed for the whole head system extending the results presented in previous publications [2]. Both SNR-and g-factors maps were obtained to compare the imaging performance of the coil with commercial head coils. Results: Sensitivity losses for the RF elements containing TMS units show a well-defined spatial pattern. Simulations indicate that the losses are predominantly caused by eddy currents on the coil wire windings. The average SNR performance of the TMSMR 28-channel coil is about 66% and 86% of the SNR of the 32/20-channel head coil respectively. The g-factor values of the TMSMR 28-channel coil are similar to the 32-channel coil and significantly better than the 20-channel coil.Conclusion: We present the TMSMR 28-channel coil, a head RF coil array to be integrated with a multichannel 3axisTMS coil system, a novel tool that will enable causal mapping of human brain function.
引用
收藏
页码:1021 / 1031
页数:11
相关论文
共 36 条
[1]   How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging [J].
Andersson, JLR ;
Skare, S ;
Ashburner, J .
NEUROIMAGE, 2003, 20 (02) :870-888
[2]   4 T Actively detuneable double-tuned 1H/31P head volume coil and four-channel 31P phased array for human brain spectroscopy [J].
Avdievich, N. T. ;
Hetherington, H. P. .
JOURNAL OF MAGNETIC RESONANCE, 2007, 186 (02) :341-346
[3]   A Review of Studies Leveraging Multimodal TMS-fMRI Applications in the Pathophysiology and Treatment of Schizophrenia [J].
Baliga, Sachin Pradeep ;
Mehta, Urvakhsh Meherwan .
FRONTIERS IN HUMAN NEUROSCIENCE, 2021, 15
[4]  
Bargmann C., 2014, Brain 2025 a scientific vision
[5]  
BARKER AT, 1985, LANCET, V1, P1106
[6]   Concurrent TMS-fMRI for causal network perturbation and proof of target engagement [J].
Bergmann, Til Ole ;
Varatheeswaran, Rathiga ;
Hanlon, Colleen A. ;
Madsen, Kristoffer H. ;
Thielscher, Axel ;
Siebner, Hartwig Roman .
NEUROIMAGE, 2021, 237
[7]   A combined TMS/fMRI study of intensity-dependent TMS over motor cortex [J].
Bohning, DE ;
Shastri, A ;
McConnell, KA ;
Nahas, Z ;
Lorberbaum, JP ;
Roberts, DR ;
Teneback, C ;
Vincent, DJ ;
George, MS .
BIOLOGICAL PSYCHIATRY, 1999, 45 (04) :385-394
[8]   Echoplanar BOLD fMRI of brain activation induced by concurrent transcranial magnetic stimulation [J].
Bohning, DE ;
Shastri, A ;
Nahas, Z ;
Lorberbaum, JP ;
Andersen, SW ;
Dannels, WR ;
Haxthausen, EU ;
Vincent, DJ ;
George, MS .
INVESTIGATIVE RADIOLOGY, 1998, 33 (06) :336-340
[9]   A 3-axis coil design for multichannel TMS arrays [J].
de Lara, Lucia I. Navarro ;
Daneshzand, Mohammad ;
Mascarenas, Anthony ;
Paulson, Douglas ;
Pratt, Kevin ;
Okadad, Yoshio ;
Raij, Tommi ;
Makarov, Sergey N. ;
Nummenmaa, Aapo .
NEUROIMAGE, 2021, 224
[10]   A novel coil array for combined TMS/fMRI experiments at 3 T [J].
de Lara, Lucia I. Navarro ;
Windischberger, Christian ;
Kuehne, Andre ;
Woletz, Michael ;
Sieg, Juergen ;
Bestmann, Sven ;
Weiskopf, Nikolaus ;
Strasser, Bernhard ;
Moser, Ewald ;
Laistler, Elmar .
MAGNETIC RESONANCE IN MEDICINE, 2015, 74 (05) :1492-1501