Synthesis of novel star-shaped calix[4]arene-based poly(2-oxazoline)s and study of their complexation with curcumin

被引：4
作者：
Kozina, N. D. [1 ]
Blokhin, A. N. [1 ]
Kirila, T. U. [1 ]
Razina, A. B. [1 ]
Bursian, A. E. [1 ]
Kurlykin, M. P. [1 ]
Filippov, A. P. [1 ]
Tenkovtsev, A. V. [1 ]
机构：
[1] Inst Macromol Cpds Russian Acad Sci, Bolshoy pr 31, St Petersburg 199004, Russia
来源：
MATERIALS TODAY COMMUNICATIONS | 2023年 / 34卷
关键词：
Star-shaped polymers; Polyoxazolines; Calix[4]arene; Curcumin; Cationic ring-opening polymerization; Grafting onto; CRITICAL MICELLE CONCENTRATION; RING-OPENING POLYMERIZATION; CRYSTAL-STRUCTURES; CATIONIC-POLYMERIZATION; POLYMERS; INITIATORS; POLY-2-ISOPROPYL-2-OXAZOLINE; SURFACTANTS; COPOLYMERS; CALIXARENE;
D O I：
10.1016/j.mtcomm.2023.105403
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A novel grafting-onto approach was applied to the synthesis of star-shaped poly(2-alkyl-2-oxazoline)s with macrocyclic calix[4]arene core. Cationic polymerizations of 2-ethyl-2-oxazoline and 2-isopropyl-2-oxazoline were terminated using calix[4]arene tetrahydrazide as a multifunctional termination agent. Molecular-weight and structural characteristics of obtained four-arm star poly(2-alkyl-2-oxazoline)s were determined by size exclusion chromatography and light scattering. The thermosensitivity of aqueous solutions of obtained star polymers was studied. Cloud points, determined for 1% wt. aqueous solutions were equal to tcp50% = 27.5 degrees C for CA4-PiPrOx and tcp50% = 73.1 degrees C for CA4-PEtOx. Critical micelle concentrations of aqueous solutions of star polymers were determined using UV-Vis absorption spectroscopy, they were equal to 2.20 x 10-4 g/mL for CA4-PEtOx and 1.68 x 10-4 g/mL for CA4-PiPrOx. It was shown that studied poly(2-alkyl-2-oxazoline)s form water-soluble complexes with hydrophobic curcumin. The composition of curcumin-polymer complexes and their stability in aqueous solutions were studied using UV-Vis absorption spectroscopy. Obtained Job's plots indicated the formation of bimolecular curcumin-polymer complexes. Binding constants of curcumin by studied calixarene-centered star polymers were equal to (5-7)x 104 L/mol.
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页数：10
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