Probiotics in the Management of Antibiotic-Associated Diarrhea in Children A Systematic Review and Meta-analysis of Randomized and Controlled Trials

被引:0
|
作者
Fadin, Larissa [1 ,2 ]
Vieira, Karolinny Cristiny de Oliveira [2 ]
Toledo, Ana Clara Campagnolo Goncalves [2 ]
da Silva, Anne Kastelianne Franca [3 ]
Pereira, Valeria Cataneli [2 ]
Winkelstroter, Lizziane Kretli [2 ,4 ]
机构
[1] Univ Western Sao Paulo, Fac Hlth Sci, UNOESTE, Presidente Prudente, SP, Brazil
[2] Univ Western Sao Paulo, Dept Microbiol, UNOESTE, Presidente Prudente, SP, Brazil
[3] Univ Estadual Paulista FCT UNESP, Dept Physiotherapy, Presidente Prudente, SP, Brazil
[4] Univ Western Sao Paulo UNOESTE, Fac Hlth Sci, Jose Bongiovani St, 700 Cidade Univ, BR-19050920 Presidente Prudente, SP, Brazil
关键词
gastrointestinal microbiome; Lactobacillus; probiotics; SACCHAROMYCES-BOULARDII; CLINICAL-TRIAL; DOUBLE-BLIND; PREVENTION; GG;
D O I
10.1097/TIN.0000000000000332
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
This review aimed to evaluate probiotic use to prevent antibiotic-associated diarrhea in children. A total of 1564 studies of randomized clinical trials published in English were found using PubMed, Cochrane, and Virtual Health Library (MEDLINE/LILACS). A meta-analysis included 4 trials in subgroup Lactobacillus rhamnosus (95% confidence interval [CI]: 0.17-0.49; P < .00001), 2 trials in subgroup L reuteri (95% CI: 0.51-1.77; P = .87), and 5 groups in subgroup association of species of probiotics (95% CI: 0.21-1.71; P = .33). The findings suggest that L rhamnosus alone may be useful in preventing antibiotic-associated diarrhea in children.
引用
收藏
页码:211 / 223
页数:13
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