Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea

被引：1

作者：

Williams, Frank B. ^{[1
,2
,5
]}

Kader, Md Abdul ^{[3
,6
]}

Dickson, Dorothy M. ^{[1
,2
]}

Colgate, E. Ross ^{[1
,2
,7
]}

Alam, Masud ^{[3
]}

Haque, Rashidul ^{[3
]}

Petri, William A. ^{[4
]}

Kirkpatrick, Beth D. ^{[1
,2
]}

Lee, Benjamin ^{[1
,2
,8
]}

机构：

[1] Univ Vermont, Larner Coll Med, Vaccine Testing Ctr, Burlington, VT USA

[2] Univ Vermont, Larner Coll Med, Translat Global Infect Dis Res Ctr, Burlington, VT USA

[3] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh

[4] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA

[5] Ochsner Hlth, New Orleans, LA USA

[6] Noakhali Sci & Technol Univ, Noakhali, Bangladesh

[7] Emmes Co, Rockville, MD USA

[8] Univ Vermont, Larner Coll Med, Translat Global Infect Dis Res Ctr, Dept Pediat, 95 Carrigan Dr,Stafford 208, Burlington, VT 05405 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 06期

基金：

美国国家卫生研究院;

关键词：

breast milk; oral vaccination; rotavirus; secretor status; ASSOCIATION;

D O I：

10.1093/ofid/ofad299

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.

引用

页数：4

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