Maternal Breast Milk Secretor Phenotype Does Not Affect Infant Susceptibility to Rotavirus Diarrhea

被引：1
作者：
Williams, Frank B. [1 ,2 ,5 ]
Kader, Md Abdul [3 ,6 ]
Dickson, Dorothy M. [1 ,2 ]
Colgate, E. Ross [1 ,2 ,7 ]
Alam, Masud [3 ]
Haque, Rashidul [3 ]
Petri, William A. [4 ]
Kirkpatrick, Beth D. [1 ,2 ]
Lee, Benjamin [1 ,2 ,8 ]
机构：
[1] Univ Vermont, Larner Coll Med, Vaccine Testing Ctr, Burlington, VT USA
[2] Univ Vermont, Larner Coll Med, Translat Global Infect Dis Res Ctr, Burlington, VT USA
[3] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh
[4] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA
[5] Ochsner Hlth, New Orleans, LA USA
[6] Noakhali Sci & Technol Univ, Noakhali, Bangladesh
[7] Emmes Co, Rockville, MD USA
[8] Univ Vermont, Larner Coll Med, Translat Global Infect Dis Res Ctr, Dept Pediat, 95 Carrigan Dr,Stafford 208, Burlington, VT 05405 USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 06期
基金：
美国国家卫生研究院;
关键词：
breast milk; oral vaccination; rotavirus; secretor status; ASSOCIATION;
D O I：
10.1093/ofid/ofad299
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.
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页数：4
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