A Case of Hypoparathyroidism in Type 1 Diabetes Mellitus

被引：0

作者：

Gohil, Namra V. ^{[1
,2
]}

Gohil, Aasvi V. ^{[3
]}

机构：

[1] Med Coll Baroda, Internal Med, Vadodara, India

[2] Shri Sayajirao Gen SSG Hosp, Vadodara, India

[3] Gujarat Med Educ & Res Soc GMERS Gotri, Pediat, Vadodara, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 04期

关键词：

vitamin d; tremors; parathyroid hormone; diabetes mellitus; hypoparathyroidism; MUTATIONS; DIAGNOSIS;

D O I：

10.7759/cureus.37746

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This case report discusses a 13-year-old female with a known history of type 1 diabetes mellitus presenting with pain in bilateral lower limbs, generalized weakness, and fatigue. After laboratory examinations, hypoparathyroidism was diagnosed based on low serum calcium, elevated serum phosphorous, and lower serum intact parathyroid hormone (PTH) levels. Treatment with calcium and vitamin D supplements led to a reduction in the patient's symptoms. The report provides an overview of the pathophysiology of hypoparathyroidism, its various etiologies, and clinical manifestations. The report emphasizes the importance of considering hypoparathyroidism as a differential diagnosis in patients with unexplained neuromuscular symptoms, even without a known thyroid disease or previous thyroid surgery.

引用

页数：3

共 9 条

[1] Hypoparathyroidism [J].

Bilezikian, John P. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (06) :1722-1736

[2] Management of Hypoparathyroidism: Summary Statement and Guidelines [J].

Brandi, Maria Luisa ;

Bilezikian, John P. ;

Shoback, Dolores ;

Bouillon, Roger ;

Clarke, Bart L. ;

Thakker, Rajesh V. ;

Khan, Aliya A. ;

Potts, John T., Jr. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (06) :2273-2283

[3] Epidemiology and Diagnosis of Hypoparathyroidism [J].

Clarke, Bart L. ;

Brown, Edward M. ;

Collins, Michael T. ;

Juppner, Harald ;

Lakatos, Peter ;

Levine, Michael A. ;

Mannstadt, Michael M. ;

Bilezikian, John P. ;

Romanischen, Anatoly F. ;

Thakker, Rajesh V. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (06) :2284-2299

[4] Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis [J].

Kaname, Tadashi ;

Ki, Chang-Seok ;

Niikawa, Norio ;

Baillie, George S. ;

Day, Jonathan P. ;

Yamamura, Ken-ichi ;

Ohta, Tohru ;

Nishimura, Gen ;

Mastuura, Nobuo ;

Kim, Ok-Hwa ;

Sohn, Young Bae ;

Kim, Hyun Woo ;

Cho, Sung Yoon ;

Ko, Ah-Ra ;

Lee, Jin Young ;

Kim, Hyun Wook ;

Ryu, Sung Ho ;

Rhee, Hwanseok ;

Yang, Kap-Seok ;

Joo, Keehyoung ;

Lee, Jooyoung ;

Kim, Chi Hwa ;

Cho, Kwang-Hyun ;

Kim, Dongsan ;

Yanagi, Kumiko ;

Naritomi, Kenji ;

Yoshiura, Ko-ichiro ;

Kondoh, Tatsuro ;

Nii, Eiji ;

Tonoki, Hidefumi ;

Houslay, Miles D. ;

Jin, Dong-Kyu .

CELLULAR SIGNALLING, 2014, 26 (11) :2446-2459

[5] An update on the clinical and molecular characteristics of pseudohypoparathyroidism [J].

Levine, Michael A. .

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2012, 19 (06) :443-451

[6] Hypoparathyroidism [J].

Mannstadt, Michael ;

Bilezikian, John P. ;

Thakker, Rajesh V. ;

Hannan, Fadil M. ;

Clarke, Bart L. ;

Reijnmark, Lars ;

Mitchell, Deborah M. ;

Vokes, Tamara J. ;

Winer, Karen K. ;

Shoback, Dolores M. .

NATURE REVIEWS DISEASE PRIMERS, 2017, 3

[7] Pseudohypoparathyroidism: Diagnosis and Treatment [J].

Mantovani, Giovanna .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (10) :3020-3030

[8] Presentation of Hypoparathyroidism: Etiologies and Clinical Features [J].

Shoback, Dolores M. ;

Bilezikian, John P. ;

Costa, Aline G. ;

Dempster, David ;

Dralle, Henning ;

Khan, Aliya A. ;

Peacock, Munro ;

Raffaelli, Marco ;

Silva, Barbara C. ;

Thakker, Rajesh V. ;

Vokes, Tamara ;

Bouillon, Roger .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (06) :2300-2312

[9] Functional Characterization of GNAS Mutations Found in Patients with Pseudohypoparathyroidism Type Ic Defines a New Subgroup of Pseudohypoparathyroidism Affecting Selectively Gsα-Receptor Interaction [J].

Thiele, Susanne ;

de Sanctis, Luisa ;

Werner, Ralf ;

Groetzinger, Joachim ;

Aydin, Cumhur ;

Jueppner, Harald ;

Bastepe, Murat ;

Hiort, Olaf .

HUMAN MUTATION, 2011, 32 (06) :653-660

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