Antifungal therapy of Candida biofilms: Past, present and future

被引：21

作者：

Ajetunmobi, Olabayo H. ^{[1
]}

Badali, Hamid ^{[1
]}

Romo, Jesus A. ^{[1
]}

Ramage, Gordon ^{[2
]}

Lopez-Ribot, Jose L. ^{[1
,3
]}

机构：

[1] Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, Dept Mol Microbiol & Immunol, San Antonio, TX USA

[2] Univ Glasgow, Coll Med, Sch Med, Glasgow Biofilm Res Network, Glasgow City G12 8TA, Scotland

[3] Univ Texas San Antonio, Dept Mol Microbiol & Immunol, One UTSA Circle, San Antonio, TX 78249 USA

来源：

BIOFILM | 2023年 / 5卷

关键词：

Antifungal agents; Candida spp; Biofilm; IN-VITRO ACTIVITY; INHIBITS HYPHAL MORPHOGENESIS; ALBICANS BIOFILM; AMPHOTERICIN-B; CASPOFUNGIN; GROWTH; ECHINOCANDINS; POTENTIATORS; COLLECTION; MECHANISMS;

D O I：

10.1016/j.bioflm.2023.100126

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Virtually all Candida species linked to clinical candidiasis are capable of forming highly resistant biofilms on different types of surfaces, which poses an additional significant threat and further complicates therapy of these infections. There is a scarcity of antifungal agents, and their effectiveness, particularly against biofilms, is limited. Here we provide a historical perspective on antifungal agents and therapy of Candida biofilms. As we reflect upon the past, consider the present, and look towards the future of antifungal therapy of Candida biofilms, we believe that there are reasons to remain optimistic, and that the major challenges of Candida biofilm therapy can be conquered within a reasonable timeframe.

引用

页数：8

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