Effect of a Novel Handheld Photobiomodulation Therapy Device in the Management of Chemoradiation Therapy-Induced Oral Mucositis in Head and Neck Cancer Patients: A Case Series Study

被引:2
作者
Jo, In-Young [1 ]
Byeon, Hyung-Kwon [2 ]
Ban, Myung-Jin [3 ]
Park, Jae-Hong [3 ]
Lee, Sang-Cheol [4 ]
Won, Yong Kyun [1 ]
Eun, Yun-Su [5 ]
Kim, Jae-Yun [5 ]
Yang, Na-Gyeong [5 ]
Lee, Sul-Hee [6 ]
Lee, Pyeongan [7 ]
Heo, Nam-Hun [8 ]
Jo, Sujin [9 ]
Seo, Hoonhee [9 ,10 ]
Kim, Sukyung [10 ]
Song, Ho-Yeon [9 ,10 ]
Kim, Jung-Eun [5 ]
机构
[1] Soonchunhyang Univ, Coll Med, Dept Radiat Oncol, Cheonan Hosp, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea
[2] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul Hosp, 59 Daesagwan Ro, Seoul 04401, South Korea
[3] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Cheonan Hosp, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea
[4] Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Hematol Oncol,Cheonan Hosp, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea
[5] Soonchunhyang Univ, Coll Med, Dept Dermatol, Cheonan Hosp, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea
[6] Soonchunhyang Univ, Coll Med, Dept Dermatol, Bucheon Hosp, 170 Jomaru Ro, Bucheon 14584, South Korea
[7] Soonchunhyang Univ, Dept Dermatol, Grad Sch Med, 22 Soonchunhyang Ro, Asan 31538, South Korea
[8] Soonchunhyang Univ, Coll Med, Clin Trial Ctr, Cheonan Hosp, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea
[9] Soonchunhyang Univ, Sch Med, Dept Microbiol & Immunol, Cheonan 31151, South Korea
[10] Soonchunhyang Univ, Probiot Microbiome Convergence Ctr, Asan 31538, South Korea
基金
新加坡国家研究基金会;
关键词
photobiomodulation; low-level laser therapy; chemoradiation= therapy; oral mucositis; head and neck cancer; case series; LEVEL LASER THERAPY; RANDOMIZED CONTROLLED-TRIAL; DOUBLE-BLIND; PHASE-III; LIGHT THERAPY; PLACEBO; RADIOTHERAPY; EFFICACY; PREVENTION; PAIN;
D O I
10.3390/photonics10030241
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Oral mucositis (OM) is a debilitating adverse event in patients undergoing treatment for cancer. This study aimed to evaluate the therapeutic effect of a novel handheld photobiomodulation therapy (PBMT) device on chemoradiation therapy (CRT)-induced OM in patients with head and neck cancer. Head and neck cancer patients undergoing CRT who developed moderate-to-severe OM during treatment were enrolled. After PBMT and at 2 and 4 weeks after PBMT, the mean value of OM grade decreased significantly from 2.63 to 2.13, 1.31, and 0.75, respectively (p < 0.05, p < 0.001, and p < 0.001). Moreover, we observed significant improvement in health-related quality of life (HRQoL) after PBMT compared to baseline through a validated questionnaire; EORTC QLQ-C30. In the present study, the use of this PBMT device in the management of CRT-induced OM in patients with head and neck cancer was generally well tolerated and resulted in the improvement of OM. However, evidence supporting its use remains lacking owing to limitations such as the small number of participants and lack of a control group. Therefore, further mechanistic studies and large-scale randomized controlled trials are needed to confirm the effectiveness of PBMT in the treatment of CRT-induced OM, as shown in our results.
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页数:18
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共 74 条
  • [1] Multi-institutional, randomized, double-blind, placebo-controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck
    Allison, Ron R.
    Ambrad, Aaron A.
    Arshoun, Youssef
    Carmel, Richard J.
    Ciuba, Doug F.
    Feldman, Elizabeth
    Finkelstein, Steven E.
    Gandhavadi, Ranjini
    Heron, Dwight E.
    Lane, Steven C.
    Longo, John M.
    Meakin, Charles
    Papadopoulos, Dimitrios
    Pruitt, David E.
    Steinbrenner, Lynn M.
    Taylor, Michael A.
    Wisbeck, William M.
    Yuh, Grace E.
    Nowotnik, David P.
    Sonis, Stephen T.
    [J]. CANCER, 2014, 120 (09) : 1433 - 1440
  • [2] A Narrative Review on Oral and Periodontal Bacteria Microbiota Photobiomodulation, through Visible and Near-Infrared Light: From the Origins to Modern Therapies
    Amaroli, Andrea
    Ravera, Silvia
    Zekiy, Angelina
    Benedicenti, Stefano
    Pasquale, Claudio
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (03)
  • [3] Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
    Anderson, Carryn M.
    Lee, Christopher M.
    Saunders, Deborah P.
    Curtis, Amarinthia
    Dunlap, Neal
    Nangia, Chaitali
    Lee, Arielle S.
    Gordon, Sharon M.
    Kovoor, Philip
    Arevalo-Araujo, Roberto
    Bar-Ad, Voichita
    Peddada, Abhinand
    Colvett, Kyle
    Miller, Douglas
    Jain, Anshu K.
    Wheeler, James
    Blakaj, Dukagjin
    Bonomi, Marcelo
    Agarwala, Sanjiv S.
    Garg, Madhur
    Worden, Francis
    Holmlund, Jon
    Brill, Jeffrey M.
    Downs, Matt
    Sonis, Stephen T.
    Katz, Sanford
    Buatti, John M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (34) : 3256 - +
  • [4] Comparison of Two Light Wavelengths (λ = 660 nm and λ = 780 nm) in the Repair Process of Oral Mucositis Induced by Ionizing Radiation: Clinical and Microscopic Evaluations in Rats
    Andrade, Maira Franco
    Sardo, Ariane Venzon Naia
    Benetti, Carolina
    Sicchieri, Leticia Bonfante
    Correa, Luciana
    Zezell, Denise Maria
    [J]. PHOTONICS, 2023, 10 (01)
  • [5] Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation
    Antunes, Heliton S.
    Herchenhorn, Daniel
    Small, Isabele A.
    Araujo, Carlos M. M.
    Pais Viegas, Celia Maria
    Cabral, Elida
    Rampini, Mariana P.
    Rodrigues, Pedro C.
    Silva, Tereza G. P.
    Ferreira, Elza M. S.
    Dias, Fernando L.
    Ferreira, Carlos G.
    [J]. RADIOTHERAPY AND ONCOLOGY, 2013, 109 (02) : 297 - 302
  • [6] A randomized controlled study for the treatment of acne vulgaris using high-intensity 414 nm solid state diode arrays
    Ash, Caerwyn
    Harrison, Anna
    Drew, Samantha
    Whittall, Rebecca
    [J]. JOURNAL OF COSMETIC AND LASER THERAPY, 2015, 17 (04) : 170 - 176
  • [7] Avci P, 2013, SEMIN CUTAN MED SURG, V32, P41
  • [8] Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis
    Barber, Claire
    Powell, Roy
    Ellis, Annie
    Hewett, Julie
    [J]. SUPPORTIVE CARE IN CANCER, 2007, 15 (04) : 427 - 440
  • [9] Basso Fernanda G., 2011, Braz. Dent. J., V22, P502, DOI 10.1590/S0103-64402011000600011
  • [10] Photobiomodulation of the microbiome: implications for metabolic and inflammatory diseases
    Bicknell, Brian
    Liebert, Ann
    Johnstone, Daniel
    Kiat, Hosen
    [J]. LASERS IN MEDICAL SCIENCE, 2019, 34 (02) : 317 - 327