Sesquiterpenoids from the Leaves of Dalbergia odorifera

被引：1

作者：

Shen, Chenxiao ^{[1
]}

Ouyang, Can Yue ^{[2
]}

Zhang, Ying ^{[2
]}

Zhu, Qing ^{[3
]}

Liu, Ronghua ^{[3
]}

Chen, Lanying ^{[2
]}

机构：

[1] Jiangxi Univ Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China

[2] Jiangxi Univ Chinese Med, Natl Pharmaceut Engn Ctr Solid Preparat Chinese H, Nanchang 330006, Jiangxi, Peoples R China

[3] Jiangxi Univ Chinese Med, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2023年 / 17卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Dalbergia odorifera leaves; sesquiterpenoids; anti-inflammatory activity;

D O I：

10.25135/rnp.347.2205.2466

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpenoids (1R,5R,6R)-11-hydroxyl-drocostuslactone (1) and (1R,10S)-gibberodione A ( 2) were acquired from the leaves of Dalbergia odorifera. The structures of the new compounds were elucidated by 1D and 2D NMR techniques, and X-ray crystallography analyses. The results of the bioactivity screening tests of the two new compounds revealed the potential anti-inflammatory effects of these two compounds, their IC50 values were 107.2 +/- 4.02 and 54.64 +/- 1.89 mu g/mL, respectively. They could significantly decrease the production of NO (P<0.01) with 8 similar to 16 and 1 similar to 2 mu g/mL and inhibited LDH (P<0.01) with 1 similar to 16 and 1 similar to 2 mu g/mL in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively.

引用

页码：265 / 274

页数：10

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