Recent advances of lanthanide nanomaterials in Tumor NIR fluorescence detection and treatment

被引:21
作者
Fan, Qi [1 ,2 ]
Sun, Chao [1 ,2 ]
Hu, Bingliang [1 ]
Wang, Quan [1 ,2 ]
机构
[1] Chinese Acad Sci, Xian Inst Opt & Precis Mech XIOPM, Key Lab Spectral Imaging Technol, Xian 710119, Peoples R China
[2] Chinese Acad Sci, Xian Inst Opt & Precis Mech XIOPM, Key Lab Biomed Spect Xian, Key Lab Spectral Imaging Technol, Xian 710119, Peoples R China
关键词
Lanthanide nanomaterials; Medical diagnosis; Therapy; Rare earths; Near infrared window; Fluorescence imaging; UP-CONVERSION NANOPARTICLES; INFRARED DOWNCONVERSION PHOTOLUMINESCENCE; 808 NM LASER; MAGNETIC-RESONANCE; IMAGING AGENTS; PHOTOTHERMAL THERAPY; ENERGY-TRANSFER; NANO-BIOPROBES; RED EMISSION; LUMINESCENCE;
D O I
10.1016/j.mtbio.2023.100646
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Lanthanide nanomaterials have garnered significant attention from researchers among the main near-infrared (NIR) fluorescent nanomaterials due to their excellent chemical and fluorescence stability, narrow emission band, adjustable luminescence color, and long lifetime. In recent years, with the preparation, functional modification, and fluorescence improvement of lanthanide materials, great progress has been made in their application in the biomedical field. This review focuses on the latest progress of lanthanide nanomaterials in tumor diagnosis and treatment, as well as the interaction mechanism between fluorescence and biological tissues. We introduce a set of efficient strategies for improving the fluorescence properties of lanthanide nanomaterials and discuss some representative in-depth research work in detail, showcasing their superiority in early detection of ultra-small tumors, phototherapy, and real-time guidance for surgical resection. However, lanthanide nanomaterials have only realized a portion of their potential in tumor applications so far. Therefore, we discuss promising methods for further improving the performance of lanthanide nanomaterials and their future development directions.
引用
收藏
页数:18
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