M-Type Phospholipase A2 Receptor Autoantibody Measured by ELISA has Diagnostic Value in Patients with Idiopathic Membranous Nephropathy

被引：1
作者：
Li, Jing [1 ]
Mulatibieke, Aerxin [1 ]
Liu, Shuyuan [2 ]
Adelibieke, Yelixiati [1 ]
Dai, Chen [1 ]
Chahan, Suolinge [1 ]
Chen, Huayun [2 ,3 ]
机构：
[1] Xinjiang Med Univ, Affiliated Hosp 1, Renal Dis Ctr, Dept Nephrol, Xinjiang, Peoples R China
[2] Guangzhou HEAS Biotech, Res & Dev Dept, Guangzhou, Peoples R China
[3] Guangzhou HEAS Biotech, 11 Kaiyuan Rd, Guangzhou 510530, Peoples R China
来源：
CLINICAL LABORATORY | 2023年 / 69卷 / 06期
关键词：
phospholipase A2 receptor; idiopathic membranous ne-phropathy; ROC curve; diagnostic performance; labora-tory tests; biopsy; ANTIBODIES; IDENTIFICATION; OUTCOMES; ANTIGEN; RATS;
D O I：
10.7754/Clin.Lab.2022.220832
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: This study investigated the diagnosis value of phospholipase A2 receptor autoantibodies (PLA2R-AB) for idiopathic membranous nephropathy (IMN).Methods: Patients with IMN, lupus nephritis, hepatitis B virus-associated nephropathy and IgA nephropathy and healthy participants were included. Receiver operating characteristics (ROC) curve was plotted for PLA2R-AB to diagnose IMN.Result: The level of serum PLA2R-AB was significantly higher in patients with IMN than with other MN, and was positively correlated to urine albumin-creatinine ratio and proteinuria in patients with IMN. The area under the ROC curve displaying the performance of PLA2R-AB to diagnose IMN was 0.907 with a sensitivity and specificity of 94.3% and 82.1%, respectively.Conclusions: PLA2R-AB is a reliable biomarker to diagnose Chinese patients with IMN.(Clin. Lab. 2023;69:1134-1140. DOI: 10.7754/Clin.Lab.2022.220832)
引用
收藏
页码：1134 / 1140
页数：7
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