M-Type Phospholipase A2 Receptor Autoantibody Measured by ELISA has Diagnostic Value in Patients with Idiopathic Membranous Nephropathy

被引：1
作者：
Li, Jing [1 ]
Mulatibieke, Aerxin [1 ]
Liu, Shuyuan [2 ]
Adelibieke, Yelixiati [1 ]
Dai, Chen [1 ]
Chahan, Suolinge [1 ]
Chen, Huayun [2 ,3 ]
机构：
[1] Xinjiang Med Univ, Affiliated Hosp 1, Renal Dis Ctr, Dept Nephrol, Xinjiang, Peoples R China
[2] Guangzhou HEAS Biotech, Res & Dev Dept, Guangzhou, Peoples R China
[3] Guangzhou HEAS Biotech, 11 Kaiyuan Rd, Guangzhou 510530, Peoples R China
来源：
CLINICAL LABORATORY | 2023年 / 69卷 / 06期
关键词：
phospholipase A2 receptor; idiopathic membranous ne-phropathy; ROC curve; diagnostic performance; labora-tory tests; biopsy; ANTIBODIES; IDENTIFICATION; OUTCOMES; ANTIGEN; RATS;
D O I：
10.7754/Clin.Lab.2022.220832
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background: This study investigated the diagnosis value of phospholipase A2 receptor autoantibodies (PLA2R-AB) for idiopathic membranous nephropathy (IMN).Methods: Patients with IMN, lupus nephritis, hepatitis B virus-associated nephropathy and IgA nephropathy and healthy participants were included. Receiver operating characteristics (ROC) curve was plotted for PLA2R-AB to diagnose IMN.Result: The level of serum PLA2R-AB was significantly higher in patients with IMN than with other MN, and was positively correlated to urine albumin-creatinine ratio and proteinuria in patients with IMN. The area under the ROC curve displaying the performance of PLA2R-AB to diagnose IMN was 0.907 with a sensitivity and specificity of 94.3% and 82.1%, respectively.Conclusions: PLA2R-AB is a reliable biomarker to diagnose Chinese patients with IMN.(Clin. Lab. 2023;69:1134-1140. DOI: 10.7754/Clin.Lab.2022.220832)
引用
收藏
页码：1134 / 1140
页数：7
相关论文
共 50 条
  • [21] The prognostic value of phospholipase A2 receptor autoantibodies on spontaneous remission for patients with idiopathic membranous nephropathy A meta-analysis
    Wu, Wenli
    Shang, Jin
    Tao, Chenyang
    Wang, Shuai
    Hu, Xiaoru
    Zhang, Shiyi
    Zhao, Zhanzheng
    MEDICINE, 2018, 97 (23)
  • [22] Phospholipase A2 receptor antibodies and clinical prognosis in patients with idiopathic membranous nephropathy: an updated systematic review and meta-analysis
    Zhang, Jialing
    Fan, Zhengjia
    Wang, Peixin
    Zhang, Ai-Hua
    KIDNEY & BLOOD PRESSURE RESEARCH, 2023, 48 (01) : 102 - 113
  • [23] The utility of phospholipase A2 receptor autoantibody in membranous nephropathy after kidney transplantation
    Xipell, Marc
    Rodas, Lida M.
    Villarreal, Jesus
    Molina, Alicia
    Reinoso-Moreno, Johanna
    Blasco, Miquel
    Poch, Esteban
    Diekmann, Fritz
    Campistol, Jose M.
    Quintana, Luis F.
    CLINICAL KIDNEY JOURNAL, 2018, 11 (03) : 422 - 428
  • [24] Serum Phospholipase A2 Receptor Antibody Is Associated with Thrombogenesis in Patients with Idiopathic Membranous Nephropathy
    Zhang, Qinling
    Liu, Guiling
    KIDNEY & BLOOD PRESSURE RESEARCH, 2024, 49 (01) : 490 - 494
  • [25] Diagnostic specificity of autoantibodies to M-type phospholipase A2 receptor (PLA2R) in differentiating idiopathic membranous nephropathy (IMN) from secondary forms and other glomerular diseases
    A. Radice
    F. Pieruzzi
    B. Trezzi
    G. Ghiggeri
    P. Napodano
    M. D’Amico
    T. Stellato
    R. Brugnano
    F. Ravera
    D. Rolla
    G. Pesce
    M. E. Giovenzana
    F. Londrino
    V. Cantaluppi
    F. Pregnolato
    A. Volpi
    G. Rombolà
    G. Moroni
    G. Ortisi
    Renato A. Sinico
    Journal of Nephrology, 2018, 31 : 271 - 278
  • [26] Anti-Phospholipase A2 Receptor Antibody as Prognostic Indicator in Idiopathic Membranous Nephropathy
    Kim, Yang Gyun
    Choi, Young-Wook
    Kim, Se-Yun
    Moon, Ju Young
    Ihm, Chun-Gyoo
    Lee, Tae Won
    Jeong, Kyung-Hwan
    Yang, Seung Hee
    Kim, Yon Su
    Oh, Yun Jung
    Lee, Sang Ho
    AMERICAN JOURNAL OF NEPHROLOGY, 2015, 42 (03) : 250 - 257
  • [27] The accuracy of the anti-phospholipase A2 receptor antibody in the diagnosis of idiopathic membranous nephropathy: a comparison of different cutoff values as measured by the ELISA method
    Dou, Yanna
    Zhang, Li
    Liu, Dong
    Wang, Chunyan
    Quan, Songxia
    Ma, Shuang
    Xiao, Jing
    Cheng, Genyang
    Liu, Zhangsuo
    Zhao, Zhanzheng
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2016, 48 (06) : 845 - 849
  • [28] The accuracy of the anti-phospholipase A2 receptor antibody in the diagnosis of idiopathic membranous nephropathy: a comparison of different cutoff values as measured by the ELISA method
    Yanna Dou
    Li Zhang
    Dong Liu
    Chunyan Wang
    Songxia Quan
    Shuang Ma
    Jing Xiao
    Genyang Cheng
    Zhangsuo Liu
    Zhanzheng Zhao
    International Urology and Nephrology, 2016, 48 : 845 - 849
  • [29] THE EXPRESSION OF M-TYPE PHOSPHOLIPASE A 2 RECEPTOR (PLA2R) AND NEPHRIN IN IDIOPATHIC MEMBRANOUS NEPHROPATHY (IMN) RENAL BIOPSY AND ITS INFLUENCE ON PROGNOSIS
    Zhang, Yan
    Xia, Gao
    Cui, Jing
    Li, Wenna
    Lv, Wei
    Lou, Jingqiu
    Qiu, Shilei
    ACTA MEDICA MEDITERRANEA, 2019, 35 (06): : 3337 - 3341
  • [30] Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan
    Yu-Huei Liu
    Cheng-Hsu Chen
    Shih-Yin Chen
    Ying-Ju Lin
    Wen-Ling Liao
    Chang-Hai Tsai
    Lei Wan
    Fuu-Jen Tsai
    Journal of Biomedical Science, 17
12345