Adipose tissue macrophages: implications for obesity-associated cancer

被引：29

作者：

Li, Bei ^{[1
]}

Sun, Si ^{[2
]}

Li, Juan-Juan ^{[3
]}

Yuan, Jing-Ping ^{[1
]}

Sun, Sheng-Rong ^{[3
]}

Wu, Qi ^{[3
,4
]}

机构：

[1] Renmin Hosp Wuhan Univ, Dept Pathol, Wuhan 430060, Peoples R China

[2] Renmin Hosp Wuhan Univ, Dept Clin Lab, Wuhan 430060, Peoples R China

[3] Renmin Hosp Wuhan Univ, Dept Breast & Thyroid Surg, Wuhan 430060, Peoples R China

[4] Tongji Univ, Tongji Univ Canc Ctr, Shanghai Peoples Hosp Tongji Univ 10, Sch Med, Shanghai 200092, Peoples R China

来源：

MILITARY MEDICAL RESEARCH | 2023年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Adipose tissue macrophages; Macrophage; Adipose; Obesity; Cancer; Therapy; TUMOR-ASSOCIATED MACROPHAGES; CALORIC RESTRICTION MIMETICS; BREAST-CANCER; ALTERNATIVE ACTIVATION; RESIDENT MACROPHAGES; METABOLIC-REGULATION; BINDING PROTEIN; GENE-EXPRESSION; GUT MICROBIOTA; TNF-ALPHA;

D O I：

10.1186/s40779-022-00437-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is one of the most serious global health problems, with an incidence that increases yearly and coincides with the development of cancer. Adipose tissue macrophages (ATMs) are particularly important in this context and contribute to linking obesity-related inflammation and tumor progression. However, the functions of ATMs on the progression of obesity-associated cancer remain unclear. In this review, we describe the origins, phenotypes, and functions of ATMs. Subsequently, we summarize the potential mechanisms on the reprogramming of ATMs in the obesity-associated microenvironment, including the direct exchange of dysfunctional metabolites, inordinate cytokines and other signaling mediators, transfer of extracellular vesicle cargo, and variations in the gut microbiota and its metabolites. A better understanding of the properties and functions of ATMs under conditions of obesity will lead to the development of new therapeutic interventions for obesity-related cancer.

引用

页数：15

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