Gold-catalyzed formal (3+2) and (4+2) cycloadditions of alkynes to highly functionalized dihydropyrroles and tetrahydropyridines

被引：7

作者：

Zhang, Xiao-Qian ^{[1
]}

Xu, Tianyi ^{[1
]}

Zhang, Congdi ^{[1
]}

Wang, Chao ^{[1
]}

Wang, Youliang ^{[1
]}

机构：

[1] Xian Jiaotong Univ XJTU, Sch Chem, MOE Key Lab Nonequilibrium Synth & Modulat Condens, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 03期

关键词：

INTERMOLECULAR 2+2 CYCLOADDITION; RADICAL-ADDITION; HYDROAMINATION; ALKALOIDS; ACETYLENE; EFFICIENT; YNAMIDES;

D O I：

10.1039/d2qo01569b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a gold-catalyzed formal cycloaddition reaction of readily available alkynes using amino but/pent-2-enoate derivatives as annulating reagents. The new strategy provides a straightforward and convergent route towards the synthesis of highly functionalized 2,3-dihydropyrroles and 1,2,3,4-tetrahydropyridines with high efficiency and a broad substrate scope. Moreover, the reaction could be facilely performed at the millimole scale and the products could be further transformed into other valuable classes of N-heterocycles.

引用

收藏

页码：680 / 685

页数：6

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