Novel insights into STAT3 in renal diseases

被引：14

作者：

Yu, Ju-tao ^{[1
]}

Fan, Shuai ^{[2
,3
]}

Li, Xiang-yu ^{[1
]}

Hou, Rui ^{[1
]}

Hu, Xiao-wei ^{[4
]}

Wang, Jia-nan ^{[1
]}

Shan, Run-run ^{[5
]}

Dong, Ze-hui ^{[1
]}

Xie, Man-man ^{[5
]}

Dong, Yu-hang ^{[1
]}

Shen, Xiao-yu ^{[1
]}

Jin, Juan ^{[6
]}

Wen, Jia-gen ^{[1
]}

Liu, Ming-ming ^{[1
]}

Wang, Wei ^{[2
,3
,7
]}

Meng, Xiao-ming ^{[1
,8
]}

机构：

[1] Anhui Med Univ, Anhui Inst Innovat Drugs,Minist Educ, Inflammat & Immune Mediated Dis Lab Anhui Prov, Key Lab Antiinflammatory & Immune Med,Sch Pharm, Hefei 230032, Peoples R China

[2] Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei 230032, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 1, Inst Urol, Dept Urol, Hefei 230032, Peoples R China

[4] Anhui Prov Childrens Hosp, Dept Clin Pharm, Hefei 230051, Peoples R China

[5] Anhui Med Univ, Sch Life Sci, Hefei 230032, Peoples R China

[6] Anhui Med Univ, Minist Educ, Key Lab Antiinflammatory & Immunopharmacol, Dept Pharmacol,Sch Basic Med Sci, Hefei 230032, Peoples R China

[7] Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei 230032, Anhui, Peoples R China

[8] Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷

基金：

中国国家自然科学基金;

关键词：

Renal diseases; STAT3; Post-translational modifications; DN; AKI; EPIDERMAL-GROWTH-FACTOR; NF-KAPPA-B; KIDNEY-DISEASE; DIABETIC-NEPHROPATHY; SIGNAL TRANSDUCER; OXIDATIVE STRESS; IGA NEPHROPATHY; FACTOR RECEPTOR; EMERGING ROLE; TGF-BETA;

D O I：

10.1016/j.biopha.2023.115166

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Signal transducer and activator of transcription 3 (STAT3) is a cell-signal transcription factor that has attracted considerable attention in recent years. The stimulation of cytokines and growth factors can result in the transcription of a wide range of genes that are crucial for several cellular biological processes involved in pro- and anti-inflammatory responses. STAT3 has attracted considerable interest as a result of a recent upsurge in study because of their role in directing the innate immune response and sustaining inflammatory pathways, which is a key feature in the pathogenesis of many diseases, including renal disorders. Several pathological conditions which may involve STAT3 include diabetic nephropathy, acute kidney injury, lupus nephritis, polycystic kidney disease, and renal cell carcinoma. STAT3 is expressed in various renal tissues under these pathological conditions. To better understand the role of STAT3 in the kidney and provide a theoretical foundation for STAT3targeted therapy for renal disorders, this review covers the current work on the activities of STAT3 and its mechanisms in the pathophysiological processes of various types of renal diseases.

引用

页数：12

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