Palladium-Catalyzed Domino Reaction for the Synthesis of 3-Amino 1,2,4-Benzothiadiazine 1,1-Dioxides

被引：4

作者：

Hommelsheim, Rene ^{[1
]}

van Nahl, Robin ^{[1
]}

Hanek, Lena M. ^{[1
]}

Ward, Jas S. ^{[2
]}

Rissanen, Kari ^{[2
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] Univ Jyvaskyla, Dept Chem, Jyvaskyla 40014, Finland

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 04期

关键词：

Domino reactions; palladium catalysis; sulfur heterocycles; sulfonamides; azides; POTASSIUM CHANNEL OPENERS; BOND-DONATING ORGANOCATALYST; PANCREATIC B-CELLS; 3-ALKYLAMINO-4H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES; PHARMACOLOGICAL EVALUATION; BIOLOGICAL EVALUATION; FACILE SYNTHESIS; INSULIN-RELEASE; WITTIG REACTION; POTENT;

D O I：

10.1002/adsc.202300875

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A palladium-catalyzed domino reaction of 2-azidosulfonamides and isocyanides enables the synthesis of 3-amino-substituted 1,2,4-benzothiadiazine 1,1-dioxides at room temperature. By applying commercially available Pd(dba)2 in catalyst loadings as low as 1.0 mol%, a variety of 21 differently substituted 2H-1,2,4-benzothiadiazine 1,1-dioxides can be prepared within 2 h. Moreover, the developed protocol gives access to the related 4H heterocycles. +image

引用

页码：717 / 724

页数：8

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