PreCancer Atlas: Present and Future

被引：12

作者：

Srivastava, Sudhir ^{[1
,3
]}

Wagner, Paul D. ^{[1
]}

Hughes, Shannon K. ^{[2
]}

Ghosh, Sharmistha ^{[2
]}

机构：

[1] NCI, Div Canc Prevent, NIH, Rockville, MD USA

[2] NCI, Div Canc Biol, NIH, Rockville, MD USA

[3] NCI, Canc Biomarkers Res Grp, Div Canc Prevent, 9609 Med Ctr Dr, Rm 5E136-9790, Bethesda, MD 20892 USA

来源：

CANCER PREVENTION RESEARCH | 2023年 / 16卷 / 07期

关键词：

CANCER; DYSPLASIA;

D O I：

10.1158/1940-6207.CAPR-22-0435

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Precancer atlases have the potential to revolutionize how we think about the topographic and morphologic structures precancerous lesions in relation to cellular, molecular, genetic, and pathophysiologic states. This mini review uses the Human Tumor Atlas Network (HTAN), established the National Cancer Institute (NCI), to illustrate the construction of cellular and molecular three-dimensional atlases of human cancers as they evolve from precancerous lesions to advanced disease. We describe the collaborative nature of the network and the research to determine how and when premalignant lesions progress to invasive cancer, regress or obtain a state of equilibrium. We have attempted to highlight progress made by HTAN in building precancer atlases and discuss possible future directions. It is hoped that the lessons from our experience with HTAN will help other investigators engaged in the construction of precancer atlases to crystallize their thoughts on logistics, rationale, and implementation.

引用

页码：379 / 384

页数：6

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