Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis

被引：8

作者：

Wang, Ling ^{[1
]}

Zhang, Qing-Qing ^{[2
]}

Xu, Yu-Yu ^{[2
]}

Zhang, Rui ^{[3
]}

Zhao, Qing ^{[2
]}

Zhang, Yu-Qing ^{[1
]}

Huang, Xue-Hong ^{[1
]}

Jiang, Bin ^{[4
]}

Ni, Min ^{[4
]}

机构：

[1] Nanjing Univ Chinese Med, Grad Sch, Nanjing 210029, Peoples R China

[2] Nanjing Med Univ, Dept Pathogen Biol, Key Lab Pathogen Jiangsu Prov, Nanjing 211166, Peoples R China

[3] Southeast Univ, Zhongda Hosp, Dept Anorectal Surg, Nanjing 210009, Peoples R China

[4] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Colorectal Dis Ctr, Nanjing 210022, Peoples R China

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2023年 / 23卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; ginsenoside Rb1; inflammation; gut microenvironment; colitis; carcinogenesis; GUT MICROBIOTA; CANCER; IMPACT; RISK; INFLAMMATION; CYTOKINES;

D O I：

10.2174/1871520623666230119092735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Colorectal cancer (CRC) is the third most common cancer worldwide. Current treatments, including surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance. Objective Therefore, it is important to find additional therapies to combat the problem. Ginsenoside Rb1 is the main active ingredient of ginseng, which is a well-known herb in traditional Chinese medicine. Ginsenoside is reported to play an important role in the prevention and treatment of cancer. Methods We established Azoxymethane (AOM)/Dextran sodium sulfate (DSS) colon cancer model based on inflammation, observed the beneficial effect of ginsenoside Rb1, and detected the changes in gut microbiota. Results Our experimental results showed that ginsenoside Rb1 significantly reduced the levels of TNF-alpha, IL-6, IL-17A, IL-33, IL-1 beta, and IL-22, increased the level of IL-10, and also changed the gut microbiota composition. These results suggested that ginsenoside Rb1 can be used to prevent inflammation-associated CRC development and may provide an effective therapeutic strategy for CRC by relieving chronic inflammation and restoring the gut microenvironment in the AOM/DSS-induced model of colitis-associated colorectal cancer in mice. Conclusion Ginsenoside Rb1 significantly attenuated AOM/DSS-induced colon carcinogenesis.

引用

页码：1067 / 1073

页数：7