Beyond mere DNA damage: Recent progress in platinum(IV) anticancer complexes containing multi-functional axial ligands

被引：31
作者：
Deng, Zhiqin [1 ,2 ]
Zhu, Guangyu [1 ,2 ]
机构：
[1] City Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China
[2] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Peoples R China
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2023年 / 74卷
基金：
中国国家自然科学基金;
关键词：
Platinum drug; Anticancer agent; Chemotherapy; Chemo-immuno-therapy; Pt(IV) prodrug; AGENTS; RESISTANCE; DELIVERY;
D O I：
10.1016/j.cbpa.2023.102303
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The clinical application of Pt-based anticancer drugs has inspired the development of novel chemotherapeutic metallo-drugs with improved efficacies. Pt(IV) prodrugs are one of the most promising successors of Pt(II) drugs and have displayed great anticancer performance. In particular, judicious modification of axial ligands endows Pt(IV) complexes with unique properties that enable them to overcome the limitations of conventional Pt(II) drugs. Herein, we summarize recent developments in Pt(IV) anticancer complexes, with a focus on their axial functionalization with other anticancer agents, immunotherapeutic agents, photosensitive ligands, peptides, and theranostic agents. We hope that this concise view of recently reported Pt(IV) coordination complexes will help re-searchers to design next-generation multi-functional anti-cancer agents based on a comprehensive Pt(IV) platform.
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页数：8
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