Estimating correlation of body mass index with Nottingham?s prognostic index in carcinoma breast

Background: Carcinoma breast, with its rising prevalence, is the cause for high mortality all over the world. Obesity plays a vital part in spread and development of cells of the tumour. It is a modifiable risk factor. Thus, lifestyle modifications including modifications in diet and increased physical activity may aid in weight loss induced alterations associated with proliferation and aggressiveness of tumour cells, their sensitivity to insulin and apoptotic ability. The present study aimed at correlating Quetelet's index (BMI) which is the most widely used indicator for obesity with Nottingham Prognostic Index (NPI). Objectives: To analyse BMI in determining proliferative potential and aggressiveness of tumour cells by establishing its correlation with the NPI in Carcinoma Breast. Methods: Prospective, observational, analytical and cross-sectional study, conducted over 60 cases of carcinoma breast that underwent modified radical mastectomy for duration of two years in the Department of Pathology in coordination with the Department of General Surgery, AVBRH, Sawangi (M), Wardha. BMI and the NPI were determined in each case and their correlation was studied through a well-tabulated master chart. Results: Statistical analysis was conducted using two tailed chi square test and Pearson's correlation coefficient. It was observed that significant association existed between BMI and tumour size, lymph node stage, BR Grade and TNM stage. Statistically significant correlation was established between BMI and NPI. Conclusion: This correlation can be used to predict outcome of patients; thus, becoming an adjunct in prognosis of breast carcinoma as well as to scheme out cost-effective strategies to reduce the plight of breast carcinoma.