The Role of a Colon-in-Continuity in Short Bowel Syndrome

被引：14

作者：

Verbiest, Astrid ^{[1
,2
]}

Jeppesen, Palle Bekker ^{[3
]}

Joly, Francisca ^{[4
,5
]}

Vanuytsel, Tim ^{[1
,2
]}

机构：

[1] Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGID, Dept Chron Dis & Metab ChroMetA, B-3000 Leuven, Belgium

[2] Univ Hosp Leuven, Leuven Intestinal Failure & Transplantat Ctr LIFT, B-3000 Leuven, Belgium

[3] Copenhagen Univ Hosp, Dept Intestinal Failure & Liver Dis, Rigshosp, DK-2100 Copenhagen, Denmark

[4] Univ Paris, Ctr Intestinal Failure, Dept Gastroenterol, IBD & Nutr Support, F-92110 Clichy, France

[5] Univ Paris, Hop Beaujon, Intestinal Stroke Ctr, UMR 1149,INSERM, F-92110 Clichy, France

来源：

NUTRIENTS | 2023年 / 15卷 / 03期

关键词：

short bowel syndrome; intestinal failure; parenteral support; colon-in-continuity; intestinal adaptation; glucagon-like peptide-2 analogs; GLUCAGON-LIKE PEPTIDE-1; PARENTERAL-NUTRITION DEPENDENCE; CHRONIC INTESTINAL FAILURE; CHAIN FATTY-ACIDS; ADULT PATIENTS; PROTEIN FERMENTATION; ABSORPTION; TEDUGLUTIDE; ADAPTATION; SECRETION;

D O I：

10.3390/nu15030628

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Short bowel syndrome (SBS) is a rare gastrointestinal condition that is defined as having less than 200 cm of remaining small intestine. SBS results from extensive surgical resection and is associated with a high risk for intestinal failure (IF) with a need for parenteral support (PS). Depending on the region of intestinal resection, three different main anatomy types can be distinguished from each other. In this review, we synthesize the current knowledge on the role of the colon in the setting of SBS-IF with a colon-in-continuity (SBS-IF-CiC), e.g., by enhancing the degree of intestinal adaptation, energy salvage, and the role of the microbiota. In addition, the effect of the disease-modifying treatment with glucagon-like peptide-2 (GLP-2) analogs in SBS-IF-CiC and how it differs from patients without a colon will be discussed. Overall, the findings explained in this review highlight the importance of preservation of the colon in SBS-IF.

引用

页数：13

共 87 条

[1] Mesenteric Infarction Clinical Outcomes After Restoration of Bowel Continuity [J].