Ketogenic nutritional therapy (KeNuT)-a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-diet therapies in endocrinology and metabolism

被引：28

作者：

Barrea, L. ^{[1
]}

Caprio, M. ^{[2
,3
]}

Camajani, E. ^{[2
,3
]}

Verde, L. ^{[4
]}

Perrini, S. ^{[5
]}

Cignarelli, A. ^{[5
]}

Prodam, F. ^{[6
,7
]}

Gambineri, A. ^{[8
,9
]}

Isidori, A. M. ^{[10
]}

Colao, A. ^{[11
,12
,13
]}

Giorgino, F. ^{[5
]}

Aimaretti, G. ^{[6
]}

Muscogiuri, G. ^{[11
,12
,13
]}

机构：

[1] Univ Telemat Pegaso, Ctr Direz, Dipartimento Sci Umanist, Isola F2, Via Porzio, I-80143 Naples, Italy

[2] IRCCS San Raffaele, Lab Cardiovasc Endocrinol, I-00166 Rome, Italy

[3] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy

[4] Univ Federico II Naples, Dept Publ Hlth, I-80131 Naples, Italy

[5] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Sect Internal Med Endocrinol Androl & Metab Dis, Bari, Italy

[6] Univ Piemonte Orientale, Dept Translat Med, Endocrinol, I-28100 Novara, Italy

[7] Univ Piemonte Orientale, Dept Hlth Sci, I-28100 Novara, Italy

[8] IRCCS Azienda Ospedaliero Univ Bologna, Div Endocrinol & Diabet Prevent & Care, Bologna, Italy

[9] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci DIMEC, Bologna, Italy

[10] Sapienza Univ Rome, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy

[11] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Un Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy

[12] Univ Napoli Federico II, Ctr Italiano cura & Benessere paziente con Obes C, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy

[13] Univ Napoli Federico II, Dipartimento Fis E Pancini, Naples, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2024年 / 47卷 / 3期

关键词：

Ketogenic diet; VLCKD; Meal replacements; Ketone bodies; Weight loss; Cardiovascular risk; Type; 2; diabetes; Cardiovascular rehabilitation; MEDITERRANEAN DIET; INSULIN-RESISTANCE; PHASE-ANGLE; WEIGHT-LOSS; ADULTS; THERMOGENESIS; SENSITIVITY; IMPEDANCE; KETOSIS;

D O I：

10.1007/s40618-023-02258-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PurposeThe ketogenic nutritional therapy (KeNuT) is an effective dietary treatment for patients with obesity and obesity-related comorbidities, including type 2 diabetes, dyslipidaemia, hypertension, coronary artery disease, and some type of cancers. However, to date an official document on the correct prescription of the ketogenic diet, validated by authoritative societies in nutrition or endocrine sciences, is missing. It is important to emphasize that the ketogenic nutritional therapy requires proper medical supervision for patient selection, due to the complex biochemical implications of ketosis and the need for a strict therapeutic compliance, and an experienced nutritionist for proper personalization of the whole nutritional protocol.MethodsThis practical guide provides an update of main clinical indications and contraindications of ketogenic nutritional therapy with meal replacements and its mechanisms of action. In addition, the various phases of the protocol involving meal replacements, its monitoring, clinical management and potential side effects, are also discussed.ConclusionThis practical guide will help the healthcare provider to acquire the necessary skills to provide a comprehensive care of patients with overweight, obesity and obesity-related diseases, using a multistep ketogenic dietary treatment, recognized by the Club of the Italian Society of Endocrinology (SIE)-Diet Therapies in Endocrinology and Metabolism.

引用

页码：487 / 500

页数：14

共 89 条

[71] Dietary variety, energy regulation, and obesity [J].