Risk Factors for Antiphospholipid Antibodies and Antiphospholipid Syndrome

被引：5
作者：
del-Pino, Rodrigo Aguirre [1 ,2 ]
Monahan, Rory C. [1 ,3 ]
Huizinga, Tom W. J. [1 ]
Eikenboom, Jeroen [4 ]
Steup-Beekman, Gerda M. [1 ,5 ]
机构：
[1] Leiden Univ Med Ctr, Dept Rheumatol, Leiden, Netherlands
[2] A Coruna Univ Hosp CHUAC, Div Rheumatol, Xubias Arriba 84, Galicia 15006, Spain
[3] Leiden Univ Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
[4] Leiden Univ Med Ctr, Dept Internal Med, Div Thrombosis & Hemostasis, Leiden, Netherlands
[5] Haaglanden Med Ctr, Dept Rheumatol, The Hague, Netherlands
来源：
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2024年 / 50卷 / 06期
关键词：
antiphospholipid syndrome; antiphospholipid antibody; thrombosis; risk factor; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTICARDIOLIPIN ANTIBODIES; VENOUS THROMBOEMBOLISM; SYNDROME SCORE; FOLLOW-UP; VITAMIN-D; CLASSIFICATION CRITERIA; CARDIOVASCULAR-DISEASE; CLINICAL-SIGNIFICANCE; RHEUMATOID-ARTHRITIS;
D O I：
10.1055/s-0043-1776910
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Persistence of serum antiphospholipid antibodies (aPL) is associated with a high thrombotic risk, both arterial and venous, and with pregnancy complications. Due to the potential morbidity and mortality associated with the presence of aPL, identifying and recognizing risk factors for the development of aPL and thrombosis in aPL carriers may help to prevent and reduce the burden of disease. Multiple elements are involved in the pathomechanism of aPL development and aPL-related thrombosis such as genetics, malignancy, and infections. This review will address the role of both well-known risk factors and their evolution, and of emerging risk factors, including COVID-19, in the development of aPL and thrombosis in aPL carriers.
引用
收藏
页码：817 / 828
页数：12
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