Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head

被引:1
作者
Peng, Peng [1 ]
He, Mincong [2 ,3 ]
Fang, Weihua [1 ]
Lai, Mengqi [1 ]
Xiao, Fangjun [1 ]
He, Wei [2 ,3 ]
Xiao, Huan [4 ]
Wei, Qiushi [2 ,3 ]
机构
[1] Guangzhou Univ Chinese Med, Guangzhou 510405, Peoples R China
[2] Guangdong Res Inst Orthoped & Traumatol Chinese Me, Guangzhou 510378, Peoples R China
[3] Guangzhou Univ Chinese Med, Affiliated Hosp 3, Dept Orthopaed, Guangzhou 510378, Peoples R China
[4] Bijie Tradit Chinese Med Hosp, Dept Orthoped, Bijie 551700, Peoples R China
关键词
Steroid-induced osteonecrosis of the femoral head; 8-hydroxy-2'-deoxyguanosine (8-OHdG); Oxidative stress; Collapse; OXIDATIVE STRESS; OSTEOCLASTOGENESIS; DNA; MECHANISMS; APOPTOSIS; DAMAGE;
D O I
10.1186/s12891-023-06804-0
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
BackgroundOxidative stress was closely related to the occurrence and development of Steroid-induced osteonecrosis of the femoral head (SIONFH). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a important index of oxidative stress. The aim of this study is to investigate the role of 8-OHdG in the development of SIONFH.MethodsFrom May 2021 and November 2021, 33 patients diagnosed with SIONFH and 26 healthy controls were recruited in this study. Assessment included the radiography and pathology evaluation of clinical bone tissue, expression position and level of 8-OHdG, level of plasma 8-OHdG, as well as the receiver operating characteristic (ROC) curve.ResultsWe observed that expression levels of 8-OHdG in bone samples decreased with Association Research Circulation Osseous (ARCO) stages. Plasma 8-OHdG levels were significantly increased in the SIONFH group compared to the healthy control group. Plasma 8-OHdG level of pre-collapse patients was higher than that of post-collapse patients, the decreased plasma 8-OHdG level was related to higher ARCO stages.ConclusionPlasma 8-OHdG may represent potential biomarkers during SIONFH at different stages. Higher plasma 8-OHdG levels indicated early stage of SIONFH. The current study provided new clues for early diagnosis and treatment for SIONFH.
引用
收藏
页数:11
相关论文
共 35 条
[21]   A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation [J].
Lee, NK ;
Choi, YG ;
Baik, JY ;
Han, SY ;
Jeong, DW ;
Bae, YS ;
Kim, N ;
Lee, SY .
BLOOD, 2005, 106 (03) :852-859
[22]   Lipoic acid prevents steroid-induced osteonecrosis in rabbits [J].
Lu, Bang-Bao ;
Li, Kang-Hua .
RHEUMATOLOGY INTERNATIONAL, 2012, 32 (06) :1679-1683
[23]   Systematic analysis of classification systems for osteonecrosis of the femoral head [J].
Mont, Michael A. ;
Marulanda, German A. ;
Jones, Lynne C. ;
Saleh, Khaled J. ;
Gordon, Noah ;
Hungerford, David S. ;
Steinberg, Marvin E. .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2006, 88A :16-26
[24]   Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today? A 5-Year Update [J].
Mont, Michael A. ;
Salem, Hytham S. ;
Piuzzi, Nicolas S. ;
Goodman, Stuart B. ;
Jones, Lynne C. .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2020, 102 (12) :1084-1099
[25]   Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease [J].
Paredes-Sanchez, Esther ;
Maria Montiel-Company, Jose ;
Enrique Iranzo-Cortes, Jose ;
Almerich-Torres, Teresa ;
Bellot-Arcis, Carlos ;
Manuel Almerich-Silla, Jose .
DISEASE MARKERS, 2018, 2018
[26]   Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway [J].
Peng, Puji ;
Nie, Zhigang ;
Sun, Fei ;
Peng, Hao .
FEBS OPEN BIO, 2021, 11 (01) :312-321
[27]   Exercise-induced oxidative stress: Friend or foe? [J].
Powers, Scott K. ;
Deminice, Rafael ;
Ozdemir, Mustafa ;
Yoshihara, Toshinori ;
Bomkamp, Matthew P. ;
Hyatt, Hayden .
JOURNAL OF SPORT AND HEALTH SCIENCE, 2020, 9 (05) :415-425
[28]   Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice [J].
Sato, Amy Y. ;
Tu, Xiaolin ;
McAndrews, Kevin A. ;
Plotkin, Lilian I. ;
Bellido, Teresita .
BONE, 2015, 73 :60-68
[29]   ROS Function in Redox Signaling and Oxidative Stress [J].
Schieber, Michael ;
Chandel, Navdeep S. .
CURRENT BIOLOGY, 2014, 24 (10) :R453-R462
[30]   Pathophysiology and risk factors for osteonecrosis [J].
Shah K.N. ;
Racine J. ;
Jones L.C. ;
Aaron R.K. .
Current Reviews in Musculoskeletal Medicine, 2015, 8 (3) :201-209