Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman-Report of a Case with 9-Year Survival

被引：0

作者：

Santonja, Carlos ^{[1
]}

Morillo-Giles, Daniel ^{[2
]}

Prieto-Pareja, Elena ^{[2
]}

Soto-de Ozaeta, Carlos ^{[2
]}

Serrano-del Castillo, Cristina ^{[2
]}

Salgado-Sanchez, Rocio ^{[2
]}

Yi-Shi, Ana-Wu-Yang ^{[1
]}

Manso, Rebeca ^{[1
]}

Rodriguez-Pinilla, Socorro Maria ^{[1
]}

机构：

[1] Hosp Univ Fdn Jimenez Diaz, Dept Pathol, Madrid 28040, Spain

[2] Hosp Univ Fdn Jimenez Diaz, Dept Haematol, Madrid 28040, Spain

来源：

MEDICINA-LITHUANIA | 2023年 / 59卷 / 09期

关键词：

anaplastic large cell lymphoma; leukaemic; ALK positive survival; case report; PERIPHERAL-BLOOD; BONE-MARROW; T-CELL; VARIANT; PHASE; INVOLVEMENT; PROGNOSIS;

D O I：

10.3390/medicina59091628

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL.

引用

页数：7

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