Anosmia (smell failure) and dysgeusia (taste distortion) in COVID-19: it is genetic

被引:2
作者
Hendaus, Mohamed A. [1 ,2 ]
机构
[1] Sidra Med, Dept Pediat, Doha 26999, Qatar
[2] Weill Cornell Med, Doha, Qatar
关键词
Anosmia; COVID-19; dysgeusia; UDP-GLUCURONOSYLTRANSFERASES; RISK; POLYMORPHISM; AMERICAN; RECEPTOR; CANCER;
D O I
10.1080/07391102.2022.2039773
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The COVID-19 pandemic is a very contagious respiratory illness with has affected millions of individuals worldwide. In addition to the well-known symptoms of any respiratory virus, COVID-19 can present with anosmia (failure to smell) and dysgeusia (distortion of the sense of taste). It appears to be a genetic link to the biological mechanisms underlying COVID-19-related anosmia and dysgeusia. Significant locus in the vicinity of the UGT2A1 and UGT2A2 genes are currently considered as the main culprit of the symptoms. However, more studies are needed to delineate a clear pathophysiology. Communicated by Ramaswamy H. Sarma
引用
收藏
页码:3162 / 3165
页数:4
相关论文
共 27 条
[1]   Frustrated and confused: The American public rates its cancer-related information-seeking experiences [J].
Arora, Neeraj K. ;
Hesse, Bradford W. ;
Rimer, Barbara K. ;
Viswanath, K. ;
Clayman, Marla L. ;
Croyle, Robert T. .
JOURNAL OF GENERAL INTERNAL MEDICINE, 2008, 23 (03) :223-228
[2]   Assessment of UGT Polymorphisms and Neonatal Jaundice [J].
Bartlett, Mark G. ;
Gourley, Glenn R. .
SEMINARS IN PERINATOLOGY, 2011, 35 (03) :127-133
[3]   Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia [J].
Brann, David H. ;
Tsukahara, Tatsuya ;
Weinreb, Caleb ;
Lipovsek, Marcela ;
Van den Berge, Koen ;
Gong, Boying ;
Chance, Rebecca ;
Macaulay, Iain C. ;
Chou, Hsin-Jung ;
Fletcher, Russell B. ;
Das, Diya ;
Street, Kelly ;
de Bezieux, Hector Roux ;
Choi, Yoon-Gi ;
Risso, Davide ;
Dudoit, Sandrine ;
Purdom, Elizabeth ;
Mill, Jonathan ;
Hachem, Ralph Abi ;
Matsunami, Hiroaki ;
Logan, Darren W. ;
Goldstein, Bradley J. ;
Grubb, Matthew S. ;
Ngai, John ;
Datta, Sandeep Robert .
SCIENCE ADVANCES, 2020, 6 (31)
[4]   Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters [J].
Bryche, Bertrand ;
St Albin, Audrey ;
Murri, Severine ;
Lacote, Sandra ;
Pulido, Coralie ;
Gouilh, Meriadeg Ar ;
Lesellier, Sandrine ;
Servat, Alexandre ;
Wasniewski, Marine ;
Picard-Meyer, Evelyne ;
Monchatre-Leroy, Elodie ;
Volmer, Romain ;
Rampin, Olivier ;
Le Goffic, Ronan ;
Marianneau, Philippe ;
Meunier, Nicolas .
BRAIN BEHAVIOR AND IMMUNITY, 2020, 89 :579-586
[5]   Olfactory Disorders and Quality of Life-An Updated Review [J].
Croy, Ilona ;
Nordin, Steven ;
Hummel, Thomas .
CHEMICAL SENSES, 2014, 39 (03) :185-194
[6]   Causes of hypogeusia/hyposmia in SARS-CoV2 infected patients [J].
Finsterer, Josef ;
Stollberger, Claudia .
JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) :1793-1794
[7]   Structure and Protein-Protein Interactions of Human UDP-Glucuronosyltransferases [J].
Fujiwara, Ryoichi ;
Yokoi, Tsuyoshi ;
Nakajima, Miki .
FRONTIERS IN PHARMACOLOGY, 2016, 7
[8]   Risk Factors for Olfactory and Gustatory Dysfunctions in Patients with SARS-CoV-2 Infection [J].
Galluzzi, Francesca ;
Rossi, Veronica ;
Bosetti, Cristina ;
Garavello, Werner .
NEUROEPIDEMIOLOGY, 2021, 55 (02) :154-161
[9]   Covid-19 induced superimposed bacterial infection [J].
Hendaus, Mohamed A. ;
Jomha, Fatima A. .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021, 39 (11) :4185-4191
[10]   Anticipated effort and morality of segregated versus aggregated volunteering [J].
Henderson, Marlone D. ;
Jung, Haesung ;
M. Baker, Erin ;
Wakslak, Cheryl J. .
JOURNAL OF BEHAVIORAL DECISION MAKING, 2021, 34 (05) :611-624