Essential oil and its nanoemulsion of Eucalyptus cladocalyx: chemical characterization, antioxidant, anti-inflammatory and anticancer activities

被引：2
|
作者：
Dakhlaoui, Sarra [1 ,2 ]
Bourgou, Soumaya [2 ]
Kalai, Feten Zar [2 ,3 ]
Hammami, Majdi [2 ]
Essafi, Makram [4 ]
Jallouli, Slim [5 ]
Msaada, Kamel [2 ]
机构：
[1] Tunis El Manar Univ, Coll Sci Tunis, Tunis, Tunisia
[2] Biotechnol Ctr Borj Cedria Technopole, Lab Aromat & Med Plants LAMP, Hammam Lif, Tunisia
[3] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Japan
[4] Pasteur Inst Tunis, Lab Transmiss Control & Immunobiol Infect LTCII, LR11 IPT02, Tunis, Tunisia
[5] Biotechnol Ctr Borj Cedria, Lab Bioact Subst LSBA, Hammam Lif, Tunisia
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH | 2024年 / 34卷 / 08期
关键词：
Eucalyptus cladocalyx; essential oil; nanoemulsion; stability; biological activities; SPONTANEOUS EMULSIFICATION; BIOLOGICAL-ACTIVITIES; STABILITY; ANTIBACTERIAL;
D O I：
10.1080/09603123.2023.2280119
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Formulating a nanoemulsion (NE) of essential oil (EO) could enhance its efficiency while requiring lower concentrations. Eucalyptus cladocalyx F. Muell EO was rich in monoterpenes hydrocarbons. NE was prepared and the effect of surfactant (Tween 20, 40 and 80) and shearing time were investigated. The results showed that the best NE was formed using Tween 80 after 25 min of emulsification. Small droplet size (40 nm), low polydispersity index PDI (0.49), and stable zeta potential highlighted the excellent NE stability which was tested under storage conditions for 4 months. The results showed that the antioxidant and anticancer activities of NE were enhanced compared to free EO. Furthermore, NE and EO exhibited high anti-inflammatory effects by inhibiting nitric oxide (NO), Interleukin 6 (IL-6), and tumor necrosis factors alpha (TNF-alpha) production in liposaccharides (LPS)-induced RAW264.7 cells. In conclusion, a stable Eucalyptus cladocalyx-NE was produced, with improved biological activities.
引用
收藏
页码：2899 / 2912
页数：14
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