Antidiabetic potential of Chia (Salvia hispanica L.) Seed Oil in streptozotocin induced diabetic rat

Chia seed oil (CSO) has biologically active components, such as vitamins, antioxidants, sterols, and others has been a subject of interest in recent years. The potential of chia seed oil to improve glucose levels and insulin tolerance, as well as regulate fasting serum insulin levels has been the focus of recent research.The aim this study was to investigate the hypoglycemic antioxidative/nitrosative, oxidative DNA damage and adenosine deaminase effects of chia seed oil on streptozotocin induced diabetes in rats. Sprague Dawley, adult, male rats were used in the study. Animals were divided into the following groups: Group I (Control, n=7), Group II (Chia Group, Chia seed oil (CSO) was applied by oral gavage at 1g/kg for 14 days, n=7), Group III ( (Diabetes (DM) Group, Streptozotocin (STZ) was applied as 50 mg/kg i.p. single dose (n=7) ), and Group IV (DM+CSO Group, STZ 50 mg/kg i.p. single dose+CSO was applied by oral gavage at 1g/kg for 14 days after diabetes was induced, (n=7) ). Physiological parameters (body weight, blood glucose) were evaluated. STZ exposure increased serum TOS, OSI and NO levels, which are markers associated with oxidative damage, while PON enzyme activities decreased compared to the control group and did not change TAS levels. Moreover, 8-OHdG level and ADA activity were increased in the diabetic groups. In addition, it was found to regulate body weight and increased glucose in the diabetic group. In line with our results, we think that chia treatment can regulate oxidative stress-mediated free radical damage caused by diabetes and may usefull as a therapeutic agent in reducing oxidative damage in diabetic subjects.