COVID-19 vaccinations in pregnancy: Save mother and baby from COVID-19 pandemic

被引:5
作者
Sunder, Amala [1 ]
Alqatari, Huda Merza [2 ]
Taha, Omer E. [2 ]
Keshta, Mohamed S. [2 ]
Bughamar, Fatima Khalid [3 ]
Darwish, Basma [1 ]
机构
[1] Bahrain Def Force Hosp, Riffa, Bahrain
[2] Royal Coll Surg Ireland Bahrain, Sch Med, Busaiteen, Bahrain
[3] King Hamad Univ Hosp, Al Sayh, Bahrain
关键词
anti-SARS-CoV-2; gestational age; latency period; maternal age; paired sample; spike and nucleocapsid proteins; transfer ratio; umbilical cord; vaccination;
D O I
10.1002/ijgo.14532
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
ObjectiveThe current study investigated the immune response of maternal coronavirus disease 2019 (COVID-19) vaccination and vertical transmission of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) and nucleocapsid (N) proteins. Study designThis retrospective study included pregnant women in Bahrain Defense Force Hospital from March 2021 to September 2021 who were vaccinated with Sinopharm or Pfizer/BioNTech. Testing of anti-N and -S levels from paired samples of maternal and umbilical cord blood was performed at the time of delivery. The immune response to vaccination, association with maternal and fetal factors, and vertical transmission of antibodies were studied. ResultsThe current study included 79 pregnant women. The median gestational age for those vaccinated with Sinopharm was 28 weeks and those vaccinated with Pfizer was 31 weeks, with 100% of the vaccinated population generating antibodies and showing vertical transmission. The anti-N and -S titers and interval frequencies varied in both vaccinations. The anti-N and -S and transfer ratio statistically correlated with maternal age, gestational age at delivery, latency period, and birth weight of the neonates differently in both vaccines. In addition, the peak level of antibodies and transfer ratios varied. ConclusionAlthough variations are exhibited in both types of vaccination, the vaccinated pregnant population generated a significant level of anti-N and -S and showed vertical transmission.
引用
收藏
页码:864 / 873
页数:10
相关论文
共 50 条
[21]   Implications of COVID-19 Pandemic on Pregnancy: Current Status and Controversies [J].
Greenberg, Grace C. ;
Vishwakarma, Nandini ;
Tirupattur, Myna Prakash ;
Sprague, Hannah M. ;
Katwa, Laxmansa C. .
COVID, 2023, 3 (06) :859-873
[22]   Pregnancy and COVID-19: past, present and future [J].
Kim, Young Keun ;
Kim, Eui Hyeok .
OBSTETRICS & GYNECOLOGY SCIENCE, 2023, 66 (03) :149-160
[23]   Vaccinations, cardiovascular drugs, hospitalization, and mortality in COVID-19 and Long COVID [J].
Dashtban, Ashkan ;
Mizani, Mehrdad A. ;
Pasea, Laura ;
Tomlinson, Christopher ;
Mu, Yi ;
Islam, Nazrul ;
Rafferty, Sarah ;
Warren-Gash, Charlotte ;
Denaxas, Spiros ;
Horstmanshof, Kim ;
Kontopantelis, Evangelos ;
Petersen, Steffen ;
Sudlow, Cathie ;
Khunti, Kamlesh ;
Banerjee, Amitava .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2024, 146
[24]   The COVID-19 pandemic and perinatology in Lithuania [J].
Tameliene, Rasa .
JOURNAL OF PEDIATRIC AND NEONATAL INDIVIDUALIZED MEDICINE, 2021, 10 (01) :1-4
[25]   COVID-19 Pandemic and Vaccine Imperialism [J].
Seretis, Stergios A. ;
Mavroudeas, Stavros D. ;
Tanik, Feride Aksu ;
Benos, Alexios ;
Kondilis, Elias .
REVIEW OF RADICAL POLITICAL ECONOMICS, 2025, 57 (01) :9-29
[26]   The COVID-19 Pandemic in Historical Perspective [J].
Bourdelais, Patrice .
HISTORICAL SOCIAL RESEARCH-HISTORISCHE SOZIALFORSCHUNG, 2021, :302-315
[27]   Reasoning in the Era of COVID-19 Pandemic [J].
Irmak, Meltem ;
Ozturk, Nilay ;
Tuncay Yueksel, Buesra ;
cakir Yildirim, Birguel ;
Karaarslan Semiz, Gueliz .
SCIENCE & EDUCATION, 2025, 34 (01) :397-421
[28]   COVID-19 pandemic and "survival of the fittest" [J].
Mukhra, Richa ;
Krishan, Kewal ;
Kanchan, Tanuj .
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2021, 15 (10) :1384-1387
[29]   COVID-19 pandemic after Omicron [J].
Lai, Christopher K. C. ;
Lam, Wilson ;
Tsang, K. Y. ;
Cheng, Frankie W. T. ;
Wong, Martin C. S. .
HONG KONG MEDICAL JOURNAL, 2022, 28 (03) :196-198
[30]   The COVID-19 pandemic in the African continent [J].
Godfrey Bwire ;
Alex Riolexus Ario ;
Patricia Eyu ;
Felix Ocom ;
Joseph F. Wamala ;
Kwadwo A. Kusi ;
Latif Ndeketa ;
Kondwani C. Jambo ;
Rhoda K. Wanyenze ;
Ambrose O. Talisuna .
BMC Medicine, 20