The critical role of platelet in cancer progression and metastasis

被引：45
作者：
Zhou, Lin [1 ]
Zhang, Zhe [2 ]
Tian, Yizhou [3 ]
Li, Zefei [3 ]
Liu, Zhongliang [3 ]
Zhu, Sibo [3 ,4 ]
机构：
[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[2] Huizhou Municipal Cent Hosp, Dept Gastrointestinal Surg, Huizhou 516001, Guangdong, Peoples R China
[3] Zhejiang Univ Tradit Chinese Med, Zhoushan Hosp Tradit Chinese Med, Dept Oncol, Zhoushan 316000, Peoples R China
[4] Fudan Univ, Sch Life Sci, Shanghai 200438, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2023年 / 28卷 / 01期
关键词：
Platelet; Metastasis; EMT; CTC; TUMOR-CELLS; ACTIVATED PLATELETS; LUNG METASTASIS; P-SELECTIN; ANGIOGENESIS; AGGREGATION; NEUTROPHILS; CARCINOMA; SURVIVAL; ASPIRIN;
D O I：
10.1186/s40001-023-01342-w
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial Mesenchymal Transition (EMT) to promote cancer progression and invasiveness. The activated platelets protect circulating tumor cells from immune surveillance and anoikis. They also mediate tumor cell arrest, extravasation and angiogenesis in distant organs through direct or indirect modulation, creating a metastatic microenvironment. This review summarizes the recent advances and progress of mechanisms in platelet activation and its interaction with cancer cells in metastasis.
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页数：12
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