Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis

被引：16

作者：

Liu, Haiyan ^{[1
]}

He, Ying ^{[2
,3
,4
]}

Gao, Xinglin ^{[1
]}

Li, Tong ^{[1
]}

Qiao, Baoxin ^{[1
]}

Tang, Lixuan ^{[1
]}

Lan, Juan ^{[1
]}

Su, Qian ^{[1
]}

Ruan, Zhiyan ^{[5
]}

Tang, Zhaoxin ^{[1
]}

Hu, Lianmei ^{[1
]}

机构：

[1] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

[2] Guangxi Vet Res Inst, Guangxi Key Lab Vet Biotechnol, Nanning 530001, Peoples R China

[3] Guangxi Key Lab Vet Biotechnol, Nanning, Guangxi, Peoples R China

[4] Minist Agr & Rural Affairs China, Key Lab China Guangxi ASEAN Cross border Anim Dis, Nanning, Peoples R China

[5] Guangdong Food & Drug Vocat Coll, Sch Pharm, 321 Longdong North Rd, Guangzhou 510520, Guangdong, Peoples R China

来源：

MYCOTOXIN RESEARCH | 2023年 / 39卷 / 04期

基金：

中国国家自然科学基金;

关键词：

AFB1; Curcumin; Mitochondrial oxidative stress; Ferritinophagy; Ferroptosis; AFLATOXIN; DAMAGE;

D O I：

10.1007/s12550-023-00504-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aflatoxin B1 (AFB1), an extremely toxic mycotoxin that extensively contaminates feed and food worldwide, poses a major hazard to poultry and human health. Curcumin, a polyphenol derived from turmeric, has attracted great attention due to its wonderful antioxidant properties. Nevertheless, effects of curcumin on the kidneys of ducks exposed to AFB1 remain unclear. Additionally, the underlying mechanism between AFB1 and ferroptosis (based on excessive lipid peroxidation) has not been sufficiently elucidated. This study aimed to investigate the protective effects and potential mechanisms of curcumin against AFB1-induced nephrotoxicity in ducklings. The results indicated that curcumin alleviated AFB1-induced growth retardation and renal distorted structure in ducklings. Concurrently, curcumin inhibited AFB1-induced mitochondrial-mediated oxidative stress by reducing the expression levels of oxidative damage markers malondialdehyde (MDA) and 8-hydroxy-2 deoxyguanosine (8-OHdG) and improved the expression of mitochondria-related antioxidant enzymes and the Nrf2 pathway. Notably, curcumin attenuated iron accumulation in the kidney, inhibited ferritinophagy via the NCOA4 pathway, and balanced iron homeostasis, thereby alleviating AFB1-induced ferroptosis in the kidney. Collectively, our results suggest that curcumin alleviates AFB1-induced nephrotoxicity in ducks by inhibiting mitochondrial-mediated oxidative stress, ferritinophagy, and ferroptosis and provide new evidence for the mechanism of AFB1-induced nephrotoxicity in ducklings treated with curcumin.

引用

页码：437 / 451

页数：15

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