Eosinophilic granulomatosis polyangiitis (EGPA) complicated with periaortitis, precipitating role of dupilumab? A case report a review of the literature

被引：5

作者：

Kai, Martine ^{[1
]}

Vion, Pierre-Adrien ^{[2
]}

Boussouar, Samia ^{[3
]}

Cacoub, Patrice ^{[1
]}

Saadoun, David ^{[1
]}

Le Joncour, Alexandre ^{[1
]}

机构：

[1] Mondor Hosp, AP HP, Dept Internal Med & Clin Immunol, Paris, France

[2] AP HP, Nucl Radiol, Paris, France

[3] AP HP, Radiol, Paris, France

来源：

RMD OPEN | 2023年 / 9卷 / 03期

关键词：

Systemic vasculitis; Inflammation; Cardiovascular Diseases; VASCULITIDES;

D O I：

10.1136/rmdopen-2023-003300

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis that affects small size vessels. Only four cases of periaortitis associated with EGPA have been reported in the literature. We report the case of a 67-year-old woman with EGPA who developed periaortitis 11 months after the initiation of dupilumab for uncontrolled asthma with hypereosinophilia. Complete remission of the periaortitis, and of EGPA, was obtained after switching from dupilumab to mepolizumab combined with oral prednisone therapy. Dupilumab has been associated with hypereosinophilia, that is usually asymptomatic and transitory, but symptomatic cases including EGPA were exceptionally reported. Although causality has not yet been established, caution is advisable when prescribing dupilumab for uncontrolled asthma with features that might suggest EGPA.

引用

页数：5

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