FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease

被引:8
作者
Ciltas, Arzuhan Cetindag [1 ]
Karabulut, Sebahattin [1 ]
Sahin, Bilal [2 ]
Filiz, Ahmet Kemal [2 ]
Yulak, Fatih [2 ]
Ozkaraca, Mustafa [3 ]
Karatas, Ozhan [3 ]
Cetin, Ali [4 ]
机构
[1] Sivas Cumhuriyet Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Sivas, Turkiye
[2] Sivas Cumhuriyet Univ, Fac Med, Dept Med Physiol, Sivas, Turkiye
[3] Sivas Cumhuriyet Univ, Fac Vet Med, Dept Vet Pathol, Sivas, Turkiye
[4] Univ Hlth Sci, Dept Obstet & Gynecol, Haseki Training & Res Hosp, Istanbul, Turkiye
关键词
Alzheimer's disease; Streptozotocin; FGF18; Rat; MITOCHONDRIAL-DNA; OXIDATIVE STRESS; GROWTH-FACTOR; DAMAGE; DEFICITS; EXPRESSION; BRAIN; FGF18;
D O I
10.1016/j.npep.2023.102367
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Alzheimer's disease (AD) is a multifactorial pathology marked by amyloid beta (A & beta;) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) exerts a neuroprotective effect in experimental models of neurodegeneration; however, how it affects AD pathology remains unknown. This study aimed to ascertain the impact of FGF18 on the behavioral and neuropathological changes in the rat model of sporadic AD induced by intracerebroventricular (ICV) injection of streptozotocin (STZ). The rats were treated with FGF18 (0.94 and 1.88 pmol, ICV) on the 15th day after STZ injection. Their cognitive function was assessed in the Morris water maze and passive avoidance tests for 5 days from the 16th to the 21st days. A & beta; levels and histological signs of neurotoxicity were detected using the enzymelinked immunosorbent assay (ELISA) assay and histopathological analysis of the brain, respectively. FGF18 mildly ameliorated the STZ-induced cognitive impairment; the A & beta; accumulation was reduced; and the neuronal damage including pyknosis and apoptosis was alleviated in the rat brain. This study highlights the promising therapeutic potential for FGF18 in managing AD.
引用
收藏
页数:8
相关论文
共 50 条
[31]   Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation [J].
Mohammadi, Negin ;
Asle-Rousta, Masoumeh ;
Rahnema, Mehdi ;
Amini, Rahim .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 910
[32]   (3-Sitosterol ameliorates the cognitive deficits and neuropathological hallmarks in an Alzheimer's disease model [J].
Sajad, Mohd ;
Ali, Rafat ;
Kumar, Rajesh ;
Khan, Nida Jamil ;
Wahab, Shadma ;
Alshehri, Saad Ali ;
Thakur, Sonu Chand .
ARABIAN JOURNAL OF CHEMISTRY, 2025, 18 (01)
[33]   Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model [J].
Fadl, N. N. ;
Ahmed, H. H. ;
Booles, H. F. ;
Sayed, A. H. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2013, 32 (07) :721-735
[34]   Knockdown of TREML2 Alleviates Neuropathological Hallmarks and Cognitive Deficiency in a Model of Sporadic Alzheimer's Disease [J].
Fu, Xin-Xin ;
Huang, Zhi-Hang ;
Wang, Shi-Yao ;
Qi, Jing-Wen ;
Luo, Zi-Jian ;
Yan, E. ;
Zhang, Ying-Dong ;
Jiang, Teng .
JOURNAL OF INFLAMMATION RESEARCH, 2024, 17 :10471-10478
[35]   Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer's disease [J].
Ramezani, Matin ;
Darbandi, Niloufar ;
Khodagholi, Fariba ;
Hashemi, Azam .
NEURAL REGENERATION RESEARCH, 2016, 11 (12) :1976-1980
[36]   Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease [J].
Sil, Susmita ;
Ghosh, Tusharkanti ;
Gupta, Pritha ;
Ghosh, Rupsa ;
Kabir, Syed N. ;
Roy, Avishek .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2016, 60 (04) :421-435
[37]   Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease [J].
Hu, Yikui ;
Li, Chengyan ;
Shen, Wei .
NEUROPATHOLOGY, 2014, 34 (04) :370-377
[38]   Declarative memory impairments in Alzheimer's disease and semantic dementia [J].
Nestor, PJ ;
Fryer, TD ;
Hodges, JR .
NEUROIMAGE, 2006, 30 (03) :1010-1020
[39]   Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer's disease [J].
Olajide, Olayemi Joseph ;
Yawson, Emmanuel Olusola ;
Gbadamosi, Ismail Temitayo ;
Arogundade, Tolulope Timothy ;
Lambe, Ezra ;
Obasi, Kosisochukwu ;
Lawal, Ismail Tayo ;
Ibrahim, Abdulmumin ;
Ogunrinola, Kehinde Yomi .
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2017, 50 :200-211
[40]   Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease? [J].
Demir, M. ;
Yilmaz, U. ;
Colak, C. ;
Cigremis, Y. ;
Ozyalin, F. ;
Tekedereli, I ;
Sandal, S. .
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2019, 120 (01) :70-77