FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease

被引：8
作者：
Ciltas, Arzuhan Cetindag [1 ]
Karabulut, Sebahattin [1 ]
Sahin, Bilal [2 ]
Filiz, Ahmet Kemal [2 ]
Yulak, Fatih [2 ]
Ozkaraca, Mustafa [3 ]
Karatas, Ozhan [3 ]
Cetin, Ali [4 ]
机构：
[1] Sivas Cumhuriyet Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Sivas, Turkiye
[2] Sivas Cumhuriyet Univ, Fac Med, Dept Med Physiol, Sivas, Turkiye
[3] Sivas Cumhuriyet Univ, Fac Vet Med, Dept Vet Pathol, Sivas, Turkiye
[4] Univ Hlth Sci, Dept Obstet & Gynecol, Haseki Training & Res Hosp, Istanbul, Turkiye
来源：
NEUROPEPTIDES | 2023年 / 101卷
关键词：
Alzheimer's disease; Streptozotocin; FGF18; Rat; MITOCHONDRIAL-DNA; OXIDATIVE STRESS; GROWTH-FACTOR; DAMAGE; DEFICITS; EXPRESSION; BRAIN; FGF18;
D O I：
10.1016/j.npep.2023.102367
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Alzheimer's disease (AD) is a multifactorial pathology marked by amyloid beta (A & beta;) accumulation, tau hyperphosphorylation, and progressive cognitive decline. Previous studies show that fibroblast growth factor 18 (FGF18) exerts a neuroprotective effect in experimental models of neurodegeneration; however, how it affects AD pathology remains unknown. This study aimed to ascertain the impact of FGF18 on the behavioral and neuropathological changes in the rat model of sporadic AD induced by intracerebroventricular (ICV) injection of streptozotocin (STZ). The rats were treated with FGF18 (0.94 and 1.88 pmol, ICV) on the 15th day after STZ injection. Their cognitive function was assessed in the Morris water maze and passive avoidance tests for 5 days from the 16th to the 21st days. A & beta; levels and histological signs of neurotoxicity were detected using the enzymelinked immunosorbent assay (ELISA) assay and histopathological analysis of the brain, respectively. FGF18 mildly ameliorated the STZ-induced cognitive impairment; the A & beta; accumulation was reduced; and the neuronal damage including pyknosis and apoptosis was alleviated in the rat brain. This study highlights the promising therapeutic potential for FGF18 in managing AD.
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页数：8
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