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Genetic and Epigenetic Features of Uveal Melanoma-An Overview and Clinical Implications
被引:8
作者:
Pasalic, Daria
[1
]
Nikuseva-Martic, Tamara
[2
]
Sekovanic, Ankica
[3
]
Kastelan, Snjezana
[4
,5
]
机构:
[1] Univ Zagreb, Sch Med, Dept Med Chem Biochem & Clin Chem, Zagreb 10000, Croatia
[2] Univ Zagreb, Sch Med, Dept Biol & Genet, Zagreb 10000, Croatia
[3] Inst Med Res & Occupat Hlth, Zagreb 10000, Croatia
[4] Univ Zagreb, Sch Med, Dept Ophthalmol & Optometry, Zagreb 10000, Croatia
[5] Clin Hosp Dubrava, Dept Ophthalmol, Zagreb 10000, Croatia
关键词:
clinical implications;
genetics;
liver function tests;
miRNA;
protein biomarkers;
uveal melanoma;
CELL PROLIFERATION;
AQUEOUS-HUMOR;
TUMOR-MARKERS;
MUTATIONS;
METASTASIS;
EXPRESSION;
MIGRATION;
GNAQ;
PROGNOSIS;
BAP1;
D O I:
10.3390/ijms241612807
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Uveal melanoma (UM) is rare, but it is the most common primary intraocular malignancy among adults. This review represents the molecular, genetic, and immunobiological mechanisms involved in UM carcinogenesis and progression, as well as data about the association of chromosomal changes, genetic mutations, selective proteins, and biochemical biomarkers with the clinical implications of UM. Genetic analysis has the potential to identify patients with a high risk of UM metastasis, enabling management that is more effective and allowing for the follow-up of patients. Advancements in molecular characterization of UM offer opportunities to develop targeted therapeutic strategies by focusing on relevant signaling pathways. Changes in miRNA expression could be useful in the diagnosis and prognosis of UM, due to unique miRNA profiles in melanoma cells or tissue and its association with metastasis. Although liver function tests do not provide enough data on the prognosis of UM, due to the high frequency of liver metastasis, liver function tests (LFTs) might be useful indicators; however, the absence of rising LFT values cannot lead to the exclusion of liver metastases. Molecular analysis of tumor tissue will allow us to identify patients with the added benefit of new therapeutic agents and provide a better insight into melanoma pathogenesis and its biological behavior.
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页数:22
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