The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton

被引：2

作者：

Alvarez, Jose Rivera ^{[1
,2
,3
,4
,5
]}

Asselin, Laure ^{[1
,2
,3
,4
,5
]}

Tilly, Peggy ^{[1
,2
,3
,4
]}

Benoit, Roxane ^{[1
,2
,3
,4
]}

Batisse, Claire ^{[1
,2
,3
,4
]}

Richert, Ludovic ^{[3
,4
,5
]}

Batisse, Julien ^{[1
,2
,3
,4
]}

Morlet, Bastien ^{[1
,2
,3
,4
]}

Levet, Florian ^{[1
,2
,3
,4
,6
,7
]}

Schwaller, Noemie ^{[1
,2
,3
,4
]}

Mely, Yves ^{[4
,5
]}

Ruff, Marc ^{[1
,2
,3
,4
]}

Reymann, Anne-Cecile ^{[1
,2
,3
,4
]}

Godin, Juliette D. ^{[1
,2
,3
,4
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire IGBMC, F-67404 Illkirch Graffenstaden, France

[2] CNRS, Ctr Natl Rech Sci, UMR7104, F-67404 Illkirch Graffenstaden, France

[3] Inst Natl Sante & Rech Medicale, INSERM, U1258, F-67404 Illkirch Graffenstaden, France

[4] Univ Strasbourg, F-67000 Strasbourg, France

[5] Ctr Natl Rech Sci, Lab Bioimagerie & Pathol, UMR 7021, F-67404 Illkirch Graffenstaden, France

[6] Univ Bordeaux, Interdisciplinary Inst Neurosci, CNRS, UMR 5297,IINS, F-33000 Bordeaux, France

[7] Univ Bordeaux, Bordeaux Imaging Ctr, CNRS, INSERM,BIC,UAR 3420,US 4, F-33600 Pessac, France

来源：

CELL REPORTS | 2023年 / 42卷 / 07期

关键词：

MICROTUBULE-ASSOCIATED PROTEIN; CENTROSOME; SPECIFICATION; MALFORMATIONS; NUCLEOKINESIS; FLUORESCENT; EXPRESSION; DISORDERS; DYNAMICS; DREBRIN;

D O I：

10.1016/j.celrep.2023.112744

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Completion of neuronal migration is critical for brain development. Kif21b is a plus-end-directed kinesin motor protein that promotes intracellular transport and controls microtubule dynamics in neurons. Here we report a physiological function of Kif21b during radial migration of projection neurons in the mouse developing cortex. In vivo analysis in mouse and live imaging on cultured slices demonstrate that Kif21b regulates the radial glia-guided locomotion of newborn neurons independently of its motility on microtubules. We show that Kif21b directly binds and regulates the actin cytoskeleton both in vitro and in vivo in migratory neurons. We establish that Kif21b-mediated regulation of actin cytoskeleton dynamics influences branching and nucleokinesis during neuronal locomotion. Altogether, our results reveal atypical roles of Kif21b on the actin cytoskeleton during migration of cortical projection neurons.

引用

页数：27

共 85 条

[81] Microtubule stabilization specifies initial neuronal polarization [J].