An early post-transplant relapse prediction score in multiple myeloma: a large cohort study from the chronic malignancies working party of EBMT

被引：5

作者：

Beksac, Meral ^{[1
]}

Iacobelli, Simona ^{[2
]}

Koster, Linda ^{[3
]}

Cornelissen, Jan ^{[4
]}

Griskevicius, Laimonas ^{[5
]}

Rabin, Neil K. ^{[6
]}

Stoppa, Anne Marie ^{[7
]}

Meijer, Ellen ^{[8
]}

Mear, Jean-Baptiste ^{[9
]}

Zeerleder, Sacha ^{[10
]}

Mayer, Jiri ^{[11
]}

Fenk, Roland ^{[12
]}

Fegueux, Nathalie ^{[13
]}

Chevallier, Patrice ^{[14
]}

Konirova, Eva ^{[15
]}

Snowden, John A. ^{[16
]}

Engelhardt, Monika ^{[17
]}

Orchard, Kim ^{[18
]}

Hulin, Cyrille ^{[19
]}

Schaap, Nicolaas ^{[20
]}

Sossa, Claudia ^{[21
]}

Elmaagacli, Ahmet ^{[22
]}

McLornan, Donal P. ^{[23
]}

Hayden, Patrick J. ^{[24
]}

Schoenland, Stefan ^{[25
]}

Yakoub-Agha, Ibrahim ^{[26
]}

机构：

[1] Ankara Univ, Ankara, Turkiye

[2] Univ Roma Tor Vergata, Rome, Italy

[3] European Soc Blood & Marrow Transplantat Leiden St, Leiden, Netherlands

[4] Erasmus Univ Med Ctr Daniel Hoed, Rotterdam, Netherlands

[5] Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania

[6] Univ Coll London Hosp NHS Fdn Trust, London, England

[7] Inst Paoli Calmettes, Marseille, France

[8] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands

[9] Ctr Hosp Univ Rennes, Rennes, France

[10] Univ Hosp Bern, Bern, Switzerland

[11] Univ Hosp Brno, Brno, Czech Republic

[12] Univ Hosp Duesseldorf, Dusseldorf, Germany

[13] CHU Lapeyronie, Montpellier, France

[14] CHU Nantes, Nantes, France

[15] Charles Univ Prague, Prague, Czech Republic

[16] Sheffield Teaching Hosp NHS Trust, Sheffield, England

[17] Univ Med Ctr Freiburg, Freiburg, Germany

[18] Univ Hosp Southampton NHS Fdn Trust, Southampton, England

[19] CHU Bordeaux, Pessac, France

[20] Radboud Univ Nijmegen, Nijmegen Med Ctr, Nijmegen, Netherlands

[21] Clin FOSCAL, Santander, Colombia

[22] Asklepios Klin St Georg, Hamburg, Germany

[23] Queens Univ Belfast, Marseille, France

[24] Trinity Coll Dublin, Sch Med, Dept Haematol, Dublin, Ireland

[25] Heidelberg Univ, Heidelberg, Germany

[26] Univ Lille, CHU Lille, Infin, Lille, France

来源：

BONE MARROW TRANSPLANTATION | 2023年 / 58卷 / 08期

关键词：

AUTOLOGOUS TRANSPLANT; POOR SURVIVAL; DEXAMETHASONE; LENALIDOMIDE; BORTEZOMIB; THERAPY; IMPACT;

D O I：

10.1038/s41409-023-01999-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Early relapse (ER) following Autologous Hematopoietic Cell Transplantation (AHCT) confers a poor prognosis. We therefore developed a novel scoring system to predict ER. A total of 14,367 AHCT-1 patients were transplanted between 2014 and 2019, and were conditioned with Melphalan 200 mg/m(2) (Mel200) (n = 7228; 2014-2017) (training cohort); Mel200 (n = 5616; 2018-2019) or Mel140 (n = 1523; 2018-2019) (validation cohorts). PFS-12 and the Cumulative Incidence of Relapse at 12 months were 84.1% and 14.7% (training Mel200), 87.2% and 11.6% (validation Mel200), and 80.3% and 16.9% (validation Mel140), respectively. The points in the risk score were: 0, 1,2 for ISS stages I, II, and III; Disease status: 0 (CR/VGPR); 1 (PR); 2 (SD/MR); 4 (Relapse/Progression); and 1 for Karnofsky <= 70. The distribution of scores: 0 (24%), 1 (33.9%), 2 (29.6 %), 3 (9.5%), and >= 4 (2.7%). The score separated PFS-12, with the lowest risk group (n = 1752) having a PFS-12 of 91.7% and the highest risk group (n = 195) 57.1%. This also applied in cytogenetically high-risk patients. If the pre-score baseline risks are 15% (standard risk) and 25% (high-risk), a score of >= 4 confers calculated risks of 38% and 54%, respectively. This novel EBMT ER score, therefore, allows for the identification of five discrete prognostic groups.

引用

页码：916 / 923

页数：8

共 21 条

[21] Development and Validation of a Simplified Score to Predict Early Relapse in Newly Diagnosed Multiple Myeloma in a Pooled Dataset of 2,190 Patients
Zaccaria, Gian Maria
Bertamini, Luca
Petrucci, Maria Teresa
Offidani, Massimo
Corradini, Paolo
Capra, Andrea
Romano, Alessandra
Liberati, Anna Marina
Mannina, Donato
de Fabritiis, Paolo
Cascavilla, Nicola
Ruggeri, Marina
Mina, Roberto
Patriarca, Francesca
Benevolo, Giulia
Belotti, Angelo
Gaidano, Gianluca
Nagler, Arnon
Hajek, Roman
Spencer, Andrew
Sonneveld, Pieter
Musto, Pellegrino
Boccadoro, Mario
Gay, Francesca
[J]. CLINICAL CANCER RESEARCH, 2021, 27 (13) : 3695 - 3703

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