An early post-transplant relapse prediction score in multiple myeloma: a large cohort study from the chronic malignancies working party of EBMT

被引：5

作者：

Beksac, Meral ^{[1
]}

Iacobelli, Simona ^{[2
]}

Koster, Linda ^{[3
]}

Cornelissen, Jan ^{[4
]}

Griskevicius, Laimonas ^{[5
]}

Rabin, Neil K. ^{[6
]}

Stoppa, Anne Marie ^{[7
]}

Meijer, Ellen ^{[8
]}

Mear, Jean-Baptiste ^{[9
]}

Zeerleder, Sacha ^{[10
]}

Mayer, Jiri ^{[11
]}

Fenk, Roland ^{[12
]}

Fegueux, Nathalie ^{[13
]}

Chevallier, Patrice ^{[14
]}

Konirova, Eva ^{[15
]}

Snowden, John A. ^{[16
]}

Engelhardt, Monika ^{[17
]}

Orchard, Kim ^{[18
]}

Hulin, Cyrille ^{[19
]}

Schaap, Nicolaas ^{[20
]}

Sossa, Claudia ^{[21
]}

Elmaagacli, Ahmet ^{[22
]}

McLornan, Donal P. ^{[23
]}

Hayden, Patrick J. ^{[24
]}

Schoenland, Stefan ^{[25
]}

Yakoub-Agha, Ibrahim ^{[26
]}

机构：

[1] Ankara Univ, Ankara, Turkiye

[2] Univ Roma Tor Vergata, Rome, Italy

[3] European Soc Blood & Marrow Transplantat Leiden St, Leiden, Netherlands

[4] Erasmus Univ Med Ctr Daniel Hoed, Rotterdam, Netherlands

[5] Vilnius Univ Hosp Santariskiu Clin, Vilnius, Lithuania

[6] Univ Coll London Hosp NHS Fdn Trust, London, England

[7] Inst Paoli Calmettes, Marseille, France

[8] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands

[9] Ctr Hosp Univ Rennes, Rennes, France

[10] Univ Hosp Bern, Bern, Switzerland

[11] Univ Hosp Brno, Brno, Czech Republic

[12] Univ Hosp Duesseldorf, Dusseldorf, Germany

[13] CHU Lapeyronie, Montpellier, France

[14] CHU Nantes, Nantes, France

[15] Charles Univ Prague, Prague, Czech Republic

[16] Sheffield Teaching Hosp NHS Trust, Sheffield, England

[17] Univ Med Ctr Freiburg, Freiburg, Germany

[18] Univ Hosp Southampton NHS Fdn Trust, Southampton, England

[19] CHU Bordeaux, Pessac, France

[20] Radboud Univ Nijmegen, Nijmegen Med Ctr, Nijmegen, Netherlands

[21] Clin FOSCAL, Santander, Colombia

[22] Asklepios Klin St Georg, Hamburg, Germany

[23] Queens Univ Belfast, Marseille, France

[24] Trinity Coll Dublin, Sch Med, Dept Haematol, Dublin, Ireland

[25] Heidelberg Univ, Heidelberg, Germany

[26] Univ Lille, CHU Lille, Infin, Lille, France

来源：

BONE MARROW TRANSPLANTATION | 2023年 / 58卷 / 08期

关键词：

AUTOLOGOUS TRANSPLANT; POOR SURVIVAL; DEXAMETHASONE; LENALIDOMIDE; BORTEZOMIB; THERAPY; IMPACT;

D O I：

10.1038/s41409-023-01999-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Early relapse (ER) following Autologous Hematopoietic Cell Transplantation (AHCT) confers a poor prognosis. We therefore developed a novel scoring system to predict ER. A total of 14,367 AHCT-1 patients were transplanted between 2014 and 2019, and were conditioned with Melphalan 200 mg/m(2) (Mel200) (n = 7228; 2014-2017) (training cohort); Mel200 (n = 5616; 2018-2019) or Mel140 (n = 1523; 2018-2019) (validation cohorts). PFS-12 and the Cumulative Incidence of Relapse at 12 months were 84.1% and 14.7% (training Mel200), 87.2% and 11.6% (validation Mel200), and 80.3% and 16.9% (validation Mel140), respectively. The points in the risk score were: 0, 1,2 for ISS stages I, II, and III; Disease status: 0 (CR/VGPR); 1 (PR); 2 (SD/MR); 4 (Relapse/Progression); and 1 for Karnofsky <= 70. The distribution of scores: 0 (24%), 1 (33.9%), 2 (29.6 %), 3 (9.5%), and >= 4 (2.7%). The score separated PFS-12, with the lowest risk group (n = 1752) having a PFS-12 of 91.7% and the highest risk group (n = 195) 57.1%. This also applied in cytogenetically high-risk patients. If the pre-score baseline risks are 15% (standard risk) and 25% (high-risk), a score of >= 4 confers calculated risks of 38% and 54%, respectively. This novel EBMT ER score, therefore, allows for the identification of five discrete prognostic groups.

引用

页码：916 / 923

页数：8

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