Scedosporium infection disseminated "from toe to head" in allogeneic stem cell transplant recipient: a case report
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作者:
Marinovic, Debra A.
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Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
Marinovic, Debra A.
[1
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Bhaimia, Eric
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Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
Bhaimia, Eric
[1
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Forrest, Graeme N.
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Rush Univ, Dept Internal Med, Div Infect Dis, Med Ctr, Chicago, IL USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
Forrest, Graeme N.
[2
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LaRue, Rebecca
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Rush Univ, Dept Pharm, Med Ctr, Chicago, IL USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
LaRue, Rebecca
[3
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Nathan, Sunita
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Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
Nathan, Sunita
[1
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Ustun, Celalettin
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Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
Ustun, Celalettin
[1
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Ward, Anna
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Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USARush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
Ward, Anna
[1
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机构:
[1] Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
[2] Rush Univ, Dept Internal Med, Div Infect Dis, Med Ctr, Chicago, IL USA
[3] Rush Univ, Dept Pharm, Med Ctr, Chicago, IL USA
BackgroundScedosporium is a lesser-known non-Aspergillus genus of mold that can present in unsuspecting ways. If overlooked, it may disseminate and cause high mortality in high-risk allogeneic stem cell transplant recipients.Case presentationThis case report describes a 65-year-old patient with Acute Myeloid Leukemia who underwent an allogeneic hematopoietic stem cell transplant after a period of prolonged neutropenia with fluconazole prophylaxis. She suffered severe debility with altered mentation from a S. apiospermum infection which likely disseminated from a toe wound to the lung and central nervous system. She was successfully treated with liposomal amphotericin B and voriconazole, but faced a prolonged recovery from physical and neurologic sequela.ConclusionsThe case highlights the importance of adequate anti-mold prophylaxis in high-risk patients, and the value of a thorough physical examination in this patient population, with particular attention to skin and soft tissue findings.
机构:
Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South Korea
Seo, Ja Young
Ma, Young Eun
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Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South Korea
Ma, Young Eun
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Lee, Jang Ho
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Lee, Seung-Tae
Ki, Chang-Seok
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Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South KoreaSungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 135710, South Korea
Ki, Chang-Seok
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Lee, Nam Yong
KOREAN JOURNAL OF LABORATORY MEDICINE,
2010,
30
(04):
: 400
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405
机构:
King Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi Arabia
Alamri, Maha
Albarrag, Ahmed M.
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King Saud Univ, Coll Med, Med Microbiol, Riyadh, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi Arabia
Albarrag, Ahmed M.
Khogeer, Haitham
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King Faisal Specialist Hosp & Res Ctr, Dept Pathol & Lab Med, Sect Hematopathol, Riyadh, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi Arabia
Khogeer, Haitham
Alburaiki, Jehad
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King Faisal Specialist Hosp & Res Ctr, Adult Cardiol, Heart Ctr, Riyadh, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi Arabia
Alburaiki, Jehad
Halim, Magid
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King Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi Arabia
Halim, Magid
Almaghrabi, Reem S.
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King Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hosp & Res Ctr, Sect Infect Dis, Dept Med, Riyadh 11211, Saudi Arabia