Scedosporium infection disseminated "from toe to head" in allogeneic stem cell transplant recipient: a case report

被引:4
|
作者
Marinovic, Debra A. [1 ]
Bhaimia, Eric [1 ]
Forrest, Graeme N. [2 ]
LaRue, Rebecca [3 ]
Nathan, Sunita [1 ]
Ustun, Celalettin [1 ]
Ward, Anna [1 ]
机构
[1] Rush Univ, Dept Internal Med, Div Hematol Oncol & Cell Therapy, Med Ctr, 1725 W Harrison St Suite 809, Chicago, IL 60612 USA
[2] Rush Univ, Dept Internal Med, Div Infect Dis, Med Ctr, Chicago, IL USA
[3] Rush Univ, Dept Pharm, Med Ctr, Chicago, IL USA
关键词
Scedosporium; Allogeneic transplant; Invasive fungal disease; Case report; OSTEOMYELITIS; APIOSPERMUM; GUIDELINES; MANAGEMENT; DIAGNOSIS;
D O I
10.1186/s12879-023-08345-2
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
BackgroundScedosporium is a lesser-known non-Aspergillus genus of mold that can present in unsuspecting ways. If overlooked, it may disseminate and cause high mortality in high-risk allogeneic stem cell transplant recipients.Case presentationThis case report describes a 65-year-old patient with Acute Myeloid Leukemia who underwent an allogeneic hematopoietic stem cell transplant after a period of prolonged neutropenia with fluconazole prophylaxis. She suffered severe debility with altered mentation from a S. apiospermum infection which likely disseminated from a toe wound to the lung and central nervous system. She was successfully treated with liposomal amphotericin B and voriconazole, but faced a prolonged recovery from physical and neurologic sequela.ConclusionsThe case highlights the importance of adequate anti-mold prophylaxis in high-risk patients, and the value of a thorough physical examination in this patient population, with particular attention to skin and soft tissue findings.
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页数:5
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