NLRP3 Inflammasome: An Emerging Therapeutic Target for Alzheimer's Disease

被引：4
|
作者：
Tao, Shuqi [1 ]
Fan, Wenyuan [1 ]
Liu, Jinmeng [2 ]
Wang, Tong [3 ]
Zheng, Haoning [1 ]
Qi, Gaoxiu [4 ]
Chen, Yanchun [2 ,5 ]
Zhang, Haoyun [2 ]
Guo, Zhangyu [1 ,2 ]
Zhou, Fenghua [2 ]
机构：
[1] Weifang Med Univ, Sch Basic Med Sci, Dept Pathol, Weifang, Shandong, Peoples R China
[2] Weifang Med Univ, Neurol Disorders & Regenerat Repair Lab, Weifang, Shandong, Peoples R China
[3] Wei Fang Peoples Hosp, Dept Neurosurg, Weifang, Shandong, Peoples R China
[4] Weifang Med Univ, Affiliated Hosp, Dept Pathol, Weifang, Shandong, Peoples R China
[5] Weifang Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Weifang, Shandong, Peoples R China
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 96卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; amyloid-beta; inhibitors; NLRP3; inflammasome; tau; treatment; NF-KAPPA-B; AMYLOID-BETA; AUTOPHAGIC DEGRADATION; COGNITIVE IMPAIRMENT; MICROGLIA; ACTIVATION; INHIBITOR; NEUROINFLAMMATION; IDENTIFICATION; PYROPTOSIS;
D O I：
10.3233/JAD-230567
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is currently the most prevalent neurological disease, and no effective and practical treatments and therapies exist. The nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domaincontaining receptor 3 (NLRP3) inflammasome is vital in the human innate immune response. However, when the NLRP3 inflammasome is overactivated by persistent stimulation, several immune-related diseases, including AD, atherosclerosis, and obesity, result. This review will focus on the composition and activation mechanism of the NLRP3 inflammasome, the relevant mechanisms of involvement in the inflammatory response to AD, and ADtreatment targeting NLRP3 inflammasome. This review aims to reveal the pathophysiological mechanism of AD from a new perspective and provide the possibility of more effective and novel strategies for preventing and treating AD.
引用
收藏
页码：1383 / 1398
页数：16
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