Progress and mechanism of graphene oxide-composited materials in application of peripheral nerve repair

被引:7
作者
Wang, Yulin [1 ,4 ]
Yang, Bing [1 ,2 ]
Huang, Zhongbing [1 ]
Yang, Zhaopu [3 ]
Wang, Juan [1 ]
Ao, Qiang [1 ,4 ]
Yin, Guangfu [1 ]
Li, Ya [1 ,4 ]
机构
[1] Sichuan Univ, Coll Biomed Engn, Chengdu, Peoples R China
[2] Sichuan Univ, Precis Med Ctr, Southwest China Hosp, Chengdu, Peoples R China
[3] Guizhou Med Prod Adm, Ctr Drug Inspect, Guiyang 550004, Peoples R China
[4] Sichuan Univ, Inst Regulatory Sci Med Devices, Chengdu, Peoples R China
关键词
Graphene oxide; Peripheral nerve injuries; Artificial nerve scaffolds; Tissue engineering; Regenerative microenvironment; NEURAL STEM-CELLS; ELECTRICAL-STIMULATION; WALLERIAN DEGENERATION; NANOFIBER SCAFFOLDS; AXON REGENERATION; INJURY; DIFFERENTIATION; BIOCOMPATIBILITY; ENHANCEMENT; CONDUITS;
D O I
10.1016/j.colsurfb.2023.113672
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Peripheral nerve injuries (PNI) are one of the most common nerve injuries, and graphene oxide (GO) has demonstrated significant potential in the treatment of PNI. GO could enhance the proliferation, adhesion, migration, and differentiation of neuronal cells by upregulating the expression of relevant proteins, and regulate the angiogenesis process and immune response. Therefore, GO is a suitable additional component for fabricating artificial nerve scaffolds (ANS), in which the slight addition of GO could improve the physicochemical performance of the matrix materials, through hydrogen bonds and electrostatic attraction. GO-composited ANS can increase the expression of nerve regeneration-associated genes and factors, promoting angiogenesis by activating the RAS/MAPK and AKT-eNOS-VEGF signaling pathway, respectively. Moreover, GO could be metabolized and excreted from the body through the pathway of peroxidase degradation in vivo. Consequently, the application of GO in PNI regeneration exhibits significant potential for transitioning from laboratory research to clinical use.
引用
收藏
页数:12
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