An Overview of the Role of Peroxisome Proliferator-activated Receptors in Liver Diseases

被引：16

作者：

Changizi, Zahra ^{[1
]}

Kajbaf, Forough ^{[2
]}

Moslehi, Azam ^{[1
,3
]}

机构：

[1] Qom Univ Med Sci, Cellular & Mol Res Ctr, Qom, Iran

[2] Islamic Azad Univ, Fac Agr, Vet Dept, Shoushtar Branch, Shoushtar, Iran

[3] Qom Univ Med Sci, Cellular & Mol Res Ctr, Qom 3715835155, Iran

来源：

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2023年 / 11卷 / 07期

关键词：

Liver; Endoplasmic reticulum stress; Nonalcoholic fatty liver dis-ease; PPAR alpha; PPAR; PPAR8/5; ENDOPLASMIC-RETICULUM STRESS; INDUCED HEPATIC STEATOSIS; PPAR-ALPHA ACTIVATION; FARNESOID X RECEPTOR; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; CROSS-TALK; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; LIPID-METABOLISM;

D O I：

10.14218/JCTH.2023.00334

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Peroxisome proliferator-activated receptors (PPARs) are a superfamily of nuclear transcription receptors, consisting of PPAR alpha, PPAR gamma, and PPAR8/5, which are highly expressed in the liver. They control and modulate the expression of a large number of genes involved in metabolism and energy homeostasis, oxidative stress, inflammation, and even apoptosis in the liver. Therefore, they have critical roles in the pathophysiology of hepatic diseases. This review provides a general insight into the role of PPARs in liver diseases and some of their agonists in the clinic.

引用

页码：1542 / 1552

页数：11

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