IL-2 mutein with diminished CD25 binding expands regulatory T cells and blocks autoimmunity

被引：0
|
作者：
Kim, James [1 ]
Eryilmaz, Ertan [2 ]
Sato, Yosuke [1 ]
Harbison, Carole [1 ]
Shaw, Mike [1 ]
机构：
[1] Takeda Pharmaceut, Tokyo, Japan
[2] Xilio Therapeut, Waltham, MA USA
来源：
JOURNAL OF IMMUNOLOGY | 2023年 / 210卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页数：1
相关论文
共 50 条
  • [31] Tuning IL-2 signaling by ADP-ribosylation of CD25
    Teege, Sophie
    Hann, Alexander
    Miksiewicz, Maria
    MacMillan, Cary
    Rissiek, Bjoern
    Buck, Friedrich
    Menzel, Stephan
    Nissen, Marion
    Bannas, Peter
    Haag, Friedrich
    Boyer, Olivier
    Seman, Michel
    Adriouch, Sahil
    Koch-Nolte, Friedrich
    SCIENTIFIC REPORTS, 2015, 5
  • [32] Tuning IL-2 signaling by ADP-ribosylation of CD25
    Sophie Teege
    Alexander Hann
    Maria Miksiewicz
    Cary MacMillan
    Björn Rissiek
    Friedrich Buck
    Stephan Menzel
    Marion Nissen
    Peter Bannas
    Friedrich Haag
    Olivier Boyer
    Michel Seman
    Sahil Adriouch
    Friedrich Koch-Nolte
    Scientific Reports, 5
  • [33] PRODUCTION OF IL-2 IN CD25 POSITIVE MALIGNANT-LYMPHOMAS
    EMILIE, D
    PEUCHMAUR, M
    GALANAUD, P
    CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 1990, 166 : 47 - 49
  • [34] Essential role for IL-2 in the early developmental steps for CD4+CD25+ regulatory T cells
    Bayer, AL
    Yu, AX
    Adeegbe, DO
    Malek, TR
    FASEB JOURNAL, 2005, 19 (04): : A8 - A8
  • [35] IL-2 induces in vivo suppression by CD4+CD25+Foxp3+ regulatory T cells
    Brandenburg, Susan
    Takahashi, Takeshi
    de la Rosa, Maurus
    Janke, Marko
    Karsten, Gabriele
    Muzzulini, Till
    Orinska, Zane
    Bulfone-Paus, Silvia
    Scheffold, Alexander
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (06) : 1643 - 1653
  • [36] Natural regulatory CD4 T cells expressing CD25
    Papiernik, M
    Banz, A
    MICROBES AND INFECTION, 2001, 3 (11) : 937 - 945
  • [37] Physiology and pathophysiology of CD4(+) CD25(+) regulatory T cells
    Boyer, Olivier
    Jacquot, Serge
    HEMATOLOGIE, 2006, 12 (03): : 164 - 170
  • [38] Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity
    Zhang, Bo
    Sun, Jiaqi
    Yuan, Yeshuang
    Ji, Dezhong
    Sun, Yeting
    Liu, Yudong
    Li, Shengjie
    Zhu, Xingxing
    Wu, Xunyao
    Hu, Jin
    Xie, Qiu
    Wu, Ling
    Liu, Lulu
    Cheng, Boyang
    Zhang, Yuanjie
    Jiang, Lingjuan
    Zhao, Lidan
    Yu, Fei
    Song, Wei
    Wang, Min
    Xu, Yue
    Ma, Shiliang
    Fei, Yunyun
    Zhang, Lihe
    Zhou, Demin
    Zhang, Xuan
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
  • [39] Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity
    Bo Zhang
    Jiaqi Sun
    Yeshuang Yuan
    Dezhong Ji
    Yeting Sun
    Yudong Liu
    Shengjie Li
    Xingxing Zhu
    Xunyao Wu
    Jin Hu
    Qiu Xie
    Ling Wu
    Lulu Liu
    Boyang Cheng
    Yuanjie Zhang
    Lingjuan Jiang
    Lidan Zhao
    Fei Yu
    Wei Song
    Min Wang
    Yue Xu
    Shiliang Ma
    Yunyun Fei
    Lihe Zhang
    Demin Zhou
    Xuan Zhang
    Signal Transduction and Targeted Therapy, 8
  • [40] Soluble CD25 imposes a low-zone IL-2 signaling environment that favors competitive outgrowth of antigen-experienced CD25high regulatory and memory T cells
    Nickle, Rebecca A.
    DeOca, Kayla B.
    Garcia, Brandon L.
    Mannie, Mark D.
    CELLULAR IMMUNOLOGY, 2023, 384
12345