IL-2 mutein with diminished CD25 binding expands regulatory T cells and blocks autoimmunity

被引:0
|
作者
Kim, James [1 ]
Eryilmaz, Ertan [2 ]
Sato, Yosuke [1 ]
Harbison, Carole [1 ]
Shaw, Mike [1 ]
机构
[1] Takeda Pharmaceut, Tokyo, Japan
[2] Xilio Therapeut, Waltham, MA USA
来源
JOURNAL OF IMMUNOLOGY | 2023年 / 210卷 / 01期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Signal transduction in CD4+CD25+ regulatory T cells:: CD25 and IL-2
    Thornton, AM
    FRONTIERS IN BIOSCIENCE, 2006, 11 : 921 - 927
  • [2] Visualizing IL-2: CD25 interactions on CD4+CD25+ regulatory cells.
    Field, Elizabeth H.
    Kulhankova, Katarina
    Dailey, Michael E.
    Rouse, Todd
    Nasr, Mohamed E.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 : 220 - 220
  • [3] An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
    Khoryati, Liliane
    Minh Nguyet Pham
    Sherve, McKenna
    Kumari, Swarnima
    Cook, Kevin
    Pearson, Josh
    Bogdani, Marika
    Campbell, Daniel J.
    Gavin, Marc A.
    SCIENCE IMMUNOLOGY, 2020, 5 (50)
  • [4] A Novel IL-2 Mutein Selectively Expands Regulatory T Cells and Prolongs Skin Graft Survival.
    Efe, O.
    Borges, T. J.
    Gassen, R. B.
    Morena, L.
    Al Jurdi, A.
    Lape, I. T.
    Bobcock, G. J.
    Madsen, J. C.
    Riella, L. V.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 : 586 - 586
  • [5] IL-3 Upregulates CD25 Expression on Human Mast Cells; Implications for IL-2 Presentation to T Regulatory Cells
    Yin, Yuzhi
    Bai, Yun
    Olivera, Ana
    Metcalfe, Dean
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (02) : AB248 - AB248
  • [6] A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease
    Peterson, Laurence B.
    Bell, Charles J. M.
    Howlett, Sarah K.
    Pekalski, Marcin L.
    Brady, Kevin
    Hinton, Heather
    Sauter, Denise
    Todd, John A.
    Umana, Pablo
    Ast, Oliver
    Waldhauer, Inja
    Freimoser-Grundschober, Anne
    Moessner, Ekkehard
    Klein, Christian
    Hosse, Ralf J.
    Wicker, Linda S.
    JOURNAL OF AUTOIMMUNITY, 2018, 95 : 1 - 14
  • [7] CD25 Shedding by Human Natural Occurring CD4+CD25+ Regulatory T Cells does not Inhibit the Action of IL-2
    Pedersen, A. E.
    Lauritsen, J. P.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2009, 70 (01) : 40 - 43
  • [8] A Long-Lived IL-2 Mutein That Selectively Activates and Expands Regulatory T Cells as a Therapy for Autoimmune Disease
    Issa, Fadi
    TRANSPLANTATION, 2019, 103 (03) : 452 - 452
  • [9] Novel IL-2Ralpha (CD25)-Binding RNA Aptamer to Target T Regulatory Cells
    Veeramani, Suresh
    Blackwell, Sue E.
    Thiel, William H.
    Giangrande, Paloma H.
    Weiner, George J.
    BLOOD, 2016, 128 (22)
  • [10] IL-2 immunotherapy for targeting regulatory T cells in autoimmunity
    Valentina Lykhopiy
    Vanshika Malviya
    Stephanie Humblet-Baron
    Susan M. Schlenner
    Genes & Immunity, 2023, 24 (5): : 248 - 262