Potential use of cidofovir, brincidofovir, and tecovirimat drugs in fighting monkeypox infection: recent trends and advancements

被引:3
|
作者
Rani, Isha [1 ]
Joshi, Hemant [2 ]
Sharma, Ujjawal [3 ]
Kaur, Jagjit [4 ]
Sood, Shivani [5 ]
Ramniwas, Seema [6 ]
Chauhan, Abhishek [7 ]
Abdulabbas, Hadi Sajid [8 ]
Tuli, Hardeep Singh [9 ]
机构
[1] Maharishi Markandeshwar Coll Med Sci & Res MMCMSR, Dept Biochem, Sadopur 134007, Ambala, India
[2] Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India
[3] Cent Univ Punjab, Sch Hlth Sci, Dept Human Genet & Mol Med, Bathinda 151401, Punjab, India
[4] Univ New South Wales, Grad Sch Biomed Engn, Fac Engn, Sydney, NSW 2052, Australia
[5] Global Inst Stem Cell Therapy & Res, GIOSTAR USA, Mohali 140308, India
[6] Chandigarh Univ, Univ Ctr Res & Dev, Univ Inst Pharmaceut Sci, Gharuan 140413, Mohali, India
[7] Amity Univ, Amity Inst Environm Toxicol Safety & Management, Noida 201303, India
[8] Univ Babylon, Dept Biol, Coll Sci, Babylon 51002, Iraq
[9] Maharishi Markandeshwar Deemed Be Univ, Dept Biosci & Technol, Maharishi Markandeshwar Engn Coll, Mullana 133207, Ambala, India
关键词
Monkeypox; Antiviral medications; Treatment; Infection; Outbreaks; Vaccines; VACCINIA VIRUS; SMALLPOX VACCINE; ANTIVIRAL TREATMENT; NONHUMAN-PRIMATES; TOPICAL CIDOFOVIR; COMPOUND ST-246; DNA VIRUS; EFFICACY; COWPOX; CMX001;
D O I
10.1007/s00210-023-02769-y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent years have witnessed the rise of more recent pandemic outbreaks including COVID-19 and monkeypox. A multinational monkeypox outbreak creates a complex situation that necessitates countermeasures to the existing quo. The first incidence of monkeypox was documented in the 1970s, and further outbreaks led to a public health emergency of international concern. Yet as of right now, neither vaccines nor medicines are certain to treat monkeypox. Even the inability of conducting human clinical trials has prevented thousands of patients from receiving effective disease management. The current state of the disease's understanding, the treatment options available, financial resources, and lastly international policies to control an epidemic state are the major obstacles to controlling epidemics. The current review focuses on the epidemiology of monkeypox, scientific ideas, and available treatments, including potential monkeypox therapeutic methods. As a result, a thorough understanding of monkeypox literature will facilitate in the development of new therapeutic medications for the prevention and treatment of monkeypox.
引用
收藏
页码:2055 / 2065
页数:11
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