Distinct dual enzyme-like activities of Fe-N-C single-atom nanozymes enable discriminative detection of cellular glutathione

被引：13

作者：

Cai, Chunqi ^{[1
]}

Zhu, Chengyang ^{[2
]}

Lv, Lingling ^{[3
]}

Huang, Pengcheng ^{[1
]}

Mao, Junjie ^{[2
]}

Wu, Fang-Ying ^{[1
]}

Deng, Ke-Yu ^{[3
]}

机构：

[1] Nanchang Univ, Sch Chem & Chem Engn, Jiangxi Prov Key Lab Modern Analyt Sci, Nanchang 330031, Peoples R China

[2] Anhui Normal Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Funct Mol Solids, Wuhu 241002, Peoples R China

[3] Nanchang Univ, Inst Translat Med, Nanchang 330031, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 75期

关键词：

Peptides;

D O I：

10.1039/d3cc03590e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fe-N-C single-atom nanozymes readily achieved discriminative detection of glutathione (GSH) over other biothiols with similar structure due to the difference between POD-like and OXD-like activities regarding the kind of reactive oxygen species. This colorimetric sensor demonstrated the heterogeneity of GSH levels in different cells and accurately monitored cellular GSH fluctuation. Discriminative detection of glutathione was readily achieved by amplifying the difference of dual enzyme-like activities of Fe-N-C single-atom nanozymes.

引用

页码：11252 / 11255

页数：4

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