Immediate exacerbation of atopic dermatitis after switching from upadacitinib to dupilumab: A report of two cases

被引：0

作者：

Ito, Makoto ^{[1
]}

Kamata, Masahiro ^{[1
,2
]}

Uchida, Hideaki ^{[1
]}

Egawa, Shota ^{[1
]}

Fukaya, Saki ^{[1
]}

Hayashi, Kotaro ^{[1
]}

Fukuyasu, Atsuko ^{[1
]}

Tanaka, Takamitsu ^{[1
]}

Ishikawa, Takeko ^{[1
]}

Tada, Yayoi ^{[1
]}

机构：

[1] Teikyo Univ, Dept Dermatol, Sch Med, Tokyo, Japan

[2] Teikyo Univ, Dept Dermatol, Sch Med, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738605, Japan

来源：

JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY | 2023年 / 6卷 / 05期

关键词：

atopic dermatitis; biologics; dupilumab; Janus kinase; upadacitinib;

D O I：

10.1002/cia2.12302

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Janus kinase (JAK) inhibitors are efficacious for atopic dermatitis (AD). However, some patients receiving JAK inhibitors develop acne, especially younger patients, or herpes zoster, especially elderly patients, and desire to switch to dupilumab. We experienced two patients with immediate exacerbation of AD after switching from upadacitinib to dupilumab, and herein report these cases. This phenomenon is attributed to the difference in elimination half-life of the two drugs and a slower onset of efficacy of dupilumab than upadacitinib. When switching from a JAK inhibitor to dupilumab, short-term concomitant use, intensifying topical treatment, and/or rescue with cyclosporine should be considered.

引用

收藏

页码：168 / 171

页数：4

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