The power and the promise of synthetic lethality for clinical application in cancer treatment

被引：7

作者：

Liu, Qian-Wen ^{[1
,2
]}

Yang, Zhi-Wen ^{[3
]}

Tang, Qing-Hai ^{[4
]}

Wang, Wen -Er ^{[5
]}

Chu, Da-Sheng ^{[6
]}

Ji, Jin-Feng ^{[7
]}

Fan, Qi-Yu ^{[8
]}

Jiang, Hong ^{[9
]}

Yang, Qin-Xin ^{[1
]}

Zhang, Hui ^{[8
]}

Liu, Xin-Yun ^{[1
]}

Xu, Xiao-Sheng ^{[10
]}

Wang, Xiao-Feng ^{[11
]}

Liu, Ji-Bin ^{[7
,8
]}

Fu, Da ^{[2
]}

Tao, Kun ^{[12
]}

Yu, Hong ^{[1
,13
]}

机构：

[1] Nanjing Med Univ, Dept Pathol, Affiliated Taizhou Peoples Hosp, Taizhou 225300, Jiangsu, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Pancreat Dis, Gen Surg,Sch Med, Shanghai 200025, Peoples R China

[3] East China Normal Univ, Changning Matern & Infant Hlth Hosp, Dept Pharm, Shanghai 200050, Peoples R China

[4] Hengyang Normal Univ, Coll Life Sci & Environm, Hunan Key Lab Conservat & Utilizat Biol Resources, Hengyang 421008, Peoples R China

[5] Hunan Normal Univ, Hosp Changsha 4, Dept Gen Surg, Changsha 410006, Hunan, Peoples R China

[6] Second Cadre Rest Med & Hlth Ctr Changning Dist, Shanghai Garrison, Shanghai 226631, Peoples R China

[7] Nantong Univ, Nantong Tumor Hosp, Dept Integrated Tradit Chinese & Western Internal, Nantong 226631, Jiangsu, Peoples R China

[8] Nantong Univ, Inst Oncol, Affiliated Tumor Hosp, Nantong 226631, Jiangsu, Peoples R China

[9] 905th Hosp Chinese Peoples Liberat Army Navy, Dept Thorac Surg, Shanghai 200050, Peoples R China

[10] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Obstet & Gynecol, Sch Med, Shanghai 200025, Peoples R China

[11] Fudan Univ, Xiamen Hosp, Zhongshan Hosp, Dept Orthoped, Xiamen 361015, Fujian, Peoples R China

[12] Tongji Univ, Tongji Hosp, Sch Med, Dept Pathol, Shanghai 200065, Peoples R China

[13] Nanjing Med Univ, Taizhou Sch Clin Med, Dept Pathol, Taizhou 225300, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 172卷

关键词：

Synthetic lethality; Cancer; Drug; DNA repair; Clinical application; BASE EXCISION-REPAIR; RELAPSED OVARIAN-CANCER; DOUBLE-STRAND BREAKS; HOMOLOGOUS-RECOMBINATION; DNA-REPAIR; URACIL-DNA; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; ARGININE METHYLTRANSFERASE; MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS;

D O I：

10.1016/j.biopha.2024.116288

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged as a significant topic in the field of targeted cancer therapy, with certain drugs based on this concept exhibiting promising outcomes in clinical trials. Nevertheless, the presence of tumor heterogeneity and the intricate DNA repair mechanisms pose challenges to the effective implementation of synthetic lethality. This review aims to explore the concepts, development, and ethical quandaries surrounding synthetic lethality. Additionally, it will provide an in-depth analysis of the clinical application and underlying mechanism of synthetic lethality.

引用

页数：12

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