Women at Altitude: Menstrual-Cycle Phase, Menopause, and Exogenous Progesterone Are Not Associated with Acute Mountain Sickness

被引：6

作者：

Gardner, Laurel ^{[1
,5
]}

Keyes, Linda E. ^{[2
]}

Phillips, Caleb ^{[1
]}

Small, Elan ^{[1
]}

Adhikari, Tejaswi ^{[3
]}

Barott, Nathan ^{[4
]}

Zafren, Ken ^{[1
]}

Maharjan, Rony ^{[3
]}

Marvel, James ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Emergency Med, Palo Alto, CA USA

[2] Univ Colorado, Sect Wilderness Med, Dept Emergency Med, Anschutz Campus, Aurora, CO USA

[3] Patan Acad Hlth Sci, Dept Gen Practice & Emergency Med, Lalitpur, Nepal

[4] SUNY Upstate Med Univ, Syracuse, NY USA

[5] Stanford Univ, Sch Med, Dept Emergency Med, Palo Alto, CA 94305 USA

来源：

HIGH ALTITUDE MEDICINE & BIOLOGY | 2024年 / 25卷 / 02期

关键词：

female sex; high-altitude illness; hormonal contraception; hormone replacement therapy; hypoxia; precision medicine; VENTILATORY RESPONSE; EXERCISE; MEDROXYPROGESTERONE;

D O I：

10.1089/ham.2023.0100

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel. Women at altitude: Menstrual-cycle phase, menopause, and exogenous progesterone are not associated with acute mountain sickness. High Alt Med Biol. 00:000-000, 2024.Background: Elevated progesterone levels in women may protect against acute mountain sickness (AMS). The impact of hormonal contraception (HC) on AMS is unknown. We examined the effect of natural and exogenous progesterone on the occurrence of AMS.Methods: We conducted a prospective observational convenience study of female trekkers in Lobuche (4,940 m) and Manang (3,519 m). We collected data on last menstrual period, use of exogenous hormones, and development of AMS.Results: There were 1,161 trekkers who met inclusion criteria, of whom 307 (26%) had AMS. There was no significant difference in occurrence of AMS between women in the follicular (28%) and the luteal (25%) phases of menstruation (p = 0.48). The proportion of premenopausal (25%) versus postmenopausal women (30%) with AMS did not differ (p = 0.33). The use of HC did not influence the occurrence of AMS (HC 23% vs. no HC 26%, p = 0.47), nor did hormonal replacement therapy (HRT) (HRT 11% vs. no HRT 31%, p = 0.13).Conclusion: We found no relationship between menstrual-cycle phase, menopausal status, or use of exogenous progesterone and the occurrence of AMS in trekkers and conclude that hormonal status is not a risk factor for AMS. Furthermore, women should not be excluded from future AMS studies based on hormonal status.

引用

页码：107 / 112

页数：6